Iron(II)-catalyzed asymmetric intramolecular olefin aminochlorination using chloride ion

Chemical Science
Cheng-Liang ZhuHao Xu

Abstract

An iron-catalyzed enantioselective and diastereoselective intramolecular olefin aminochlorination reaction is reported (ee up to 92%, dr up to 15 : 1). In this reaction, a functionalized hydroxylamine and chloride ion are utilized as nitrogen and chlorine sources, respectively. This new method tolerates a range of synthetically valuable internal olefins that are all incompatible with existing asymmetric olefin aminochlorination methods.

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Citations

Mar 30, 2016·Chemical Communications : Chem Comm·Yasuhiro SawamuraKazuaki Ishihara
Jun 25, 2016·Chemical Reviews·David A PetroneMark Lautens
Aug 17, 2016·Journal of the American Chemical Society·Deng-Fu LuHao Xu
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May 26, 2018·Chemistry : a European Journal·Anne-Doriane ManickGuillaume Prestat
Oct 19, 2017·Chemistry : a European Journal·Yoshihiro NagaoYoshitaka Hamashima
Mar 19, 2021·Organic & Biomolecular Chemistry·Ziying WuHuanfeng Jiang
Jun 8, 2021·Organic & Biomolecular Chemistry·Bruna Papa SpadaforaAlessandro Rodrigues
Jun 11, 2019·Journal of the American Chemical Society·Seung Youn Hong, Sukbok Chang

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Methods Mentioned

BETA
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