Iron(III) catalysed synthesis of unsymmetrical di and trisubstituted ureas--a variation of classical Ritter reaction

Organic & Biomolecular Chemistry
Hosamani Basavaprabhu, Vommina V Sureshbabu

Abstract

An application of the classical Ritter reaction for the synthesis of unsymmetrical di and trisubstituted ureas catalyzed by FeCl(3) is described. The protocol is of significant interest in view of the easy availability of precursors, mild reaction conditions employed and interestingly its applicability for the alkylation of alcohols capable of forming stable carbocationic intermediates even to the sterically hindered moieties.

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Citations

Apr 25, 2014·The Journal of Organic Chemistry·Liliana Becerra-FigueroaDiego Gamba-Sánchez
Jul 20, 2017·The Journal of Organic Chemistry·Kristina HolzschneiderStefan F Kirsch
Mar 10, 2015·Chemical Reviews·Ingmar Bauer, Hans-Joachim Knölker

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