Iron(III) Schiff base complexes of arginine and lysine as netropsin mimics showing AT-selective DNA binding and photonuclease activity

Journal of Inorganic Biochemistry
Mohammed S Ameerunisha BegumAkhil R Chakravarty

Abstract

Iron(III) complexes [Fe(L)(2)]Cl (1-3), where L is monoanionic N-salicylidene-arginine (sal-argH for 1), hydroxynaphthylidene-arginine (nap-argH for 2) and N-salicylidene-lysine (sal-lysH for 3), were prepared and their DNA binding and photo-induced DNA cleavage activity studied. Complex 3 as its hexafluorophosphate salt [Fe(sal-lysH)(2)](PF(6)).6H(2)O (3a) was structurally characterized by single crystal X-ray crystallography. The crystals belonged to the triclinic space group P-1. The complex has two tridentate ligands in FeN(2)O(4) coordination geometry with two pendant cationic amine moieties. Complexes 1 and 2 with two pendant cationic guanidinium moieties are the structural models for the antitumor antibiotics netropsin. The complexes are stable and soluble in water. They showed quasi-reversible Fe(III)/Fe(II) redox couple near 0.6V in H(2)O-0.1M KCl. The high-spin 3d(5)-iron(III) complexes with mu(eff) value of approximately 5.9 mu(B) displayed ligand-to-metal charge transfer electronic band near 500nm in Tris-HCl buffer. The complexes show binding to Calf Thymus (CT) DNA. Complex 2 showed better binding propensity to the synthetic oligomer poly(dA).poly(dT) than to CT-DNA or poly(dG).poly(dC). All the complexes displaye...Continue Reading

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Citations

Jun 27, 2012·Journal of Biomolecular Structure & Dynamics·Reza SilaviAli Akbar Saboury
Mar 23, 2013·Journal of Fluorescence·Maryam Nejat Dehkordi, Per Lincoln
Oct 6, 2010·Dalton Transactions : an International Journal of Inorganic Chemistry·Gong-Jun ChenShi-Ping Yan

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