PMID: 589840Aug 1, 1977

Irradiation-induced changes in human salivary glands

Clinical Otolaryngology and Allied Sciences
A Busuttil

Abstract

Salivary tissue shows inflammatory changes, atrophy, replacement fibrosis, marked pleomorphism and atypia of the acinar epithelium and oncocytic metaplasia in the months following irradiation. The ductular epithelium undergoes squamous changes and within the ductular lumina, secretions become inspissated. The underlying pathogenetic mechanisms for these late irradiation induced changes may be the combination of a direct irradiation effect on acinar epithelium in association with post-obstructive inflammation and ischaemia, secondary to irradiation-induced endarteritis; however, these morphological changes observed may only be the result of an unusual repair phenomenon that salivary tissue is known to go through after any form of noxious stimulation. These histological alterations may lead to a possible misdiagnosis of malignancy in surgical specimens.

References

Mar 1, 1976·The Journal of Laryngology and Otology·A Busuttil
Aug 1, 1972·Archives of Oral Biology·N E Pratt, M Sodicoff
Nov 8, 1968·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·H A van den Brenk
Jul 1, 1971·Archives of Otolaryngology·L R Eversole, W R Sabes
Feb 1, 1955·Journal of Dental Research·J A ENGLISH
Sep 1, 1959·The British Journal of Radiology·C P CHERRY, A GLUCKSMANN

Citations

Sep 17, 2002·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Reinhard E FriedrichChristine Lautenschläger
Mar 1, 1980·Annals of Surgery·S F Sener, E F Scanlon
Nov 1, 1991·Special Care in Dentistry : Official Publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry·I H Valdez
Dec 21, 2005·Virchows Archiv : an International Journal of Pathology·Andrea Ambrosini-SpaltroGiuseppe Viale
May 1, 1978·Clinical Otolaryngology and Allied Sciences·A Busuttil
Feb 2, 2006·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Paulo Rogério Ferreti BonanOslei Paes de Almeida
Jul 21, 2005·International Journal of Radiation Oncology, Biology, Physics·J LiSonglin Wang
Jan 25, 2017·Biochimica Et Biophysica Acta. Bioenergetics·Monica De LuiseGiuseppe Gasparre
Mar 1, 1987·Head & Neck Surgery·L J ShemenR H Spiro
Nov 1, 1981·Head & Neck Surgery·E F Scanlon, S F Sener

Related Concepts

Atrophic
Neoplastic Cell Transformation
Misdiagnosis
Endarteritis
Cancer of Neck
Metaplasia
Radiation-Induced Cancer
Radiation Syndrome
Radiotherapy, Targeted
Malignant Neoplasm of Salivary Gland

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