Irradiation-induced progenitor cell death in the developing brain is resistant to erythropoietin treatment and caspase inhibition

Cell Death and Differentiation
H FukudaK Blomgren

Abstract

One hemisphere of postnatal day 8 (P8) rats or P10 mice was irradiated with a single dose of 4-12 Gy, and animals were killed from 2 h to 8 weeks after irradiation (IR). In the subventricular zone (SVZ) and the granular cell layer (GCL) of the dentate gyrus, harboring neural and other progenitor cells, nitrosylation and p53 peaked 2-12 h after IR, followed by markers for active caspase-3, apoptosis-inducing factor and TUNEL (6-24 h). Ki67-positive (proliferating) cells had disappeared by 12 h and partly reappeared by 7 days post-IR. The SVZ and GCL areas decreased approximately 50% 7 days after IR. The development of white matter was hampered, resulting in 50-70% less myelin basic protein staining. Pretreatment with erythropoietin did not confer protection against IR. Caspase inhibition by overexpression of XIAP prevented caspase-9 and caspase-3 activation but not cell death, presumably because of increased caspase-independent cell death.

References

Jan 1, 1990·Medical and Pediatric Oncology·B LanneringE Olsson
Aug 1, 1989·The British Journal of Radiology·J F Fowler
Jan 1, 1987·Medical and Pediatric Oncology·R J PackerG D'Angio
May 1, 1988·Archives of Disease in Childhood·E A Livesey, C G Brook
Jul 15, 1986·Cancer·G D Hammond
Jul 1, 1984·Cancer·F P LiK Gimbrere
Feb 1, 1981·Annals of Neurology·J E RiceJ B Brierley
Mar 30, 1995·International Journal of Radiation Oncology, Biology, Physics·T E SchultheissL C Stephens
May 1, 1994·International Journal of Radiation Biology·Z J SienkiewiczR D Saunders
May 13, 1998·Behavioural Brain Research·H HodgesM Rezvani
Apr 9, 1999·Nature Neuroscience·E GouldT J Shors
Jul 17, 1999·Brain Research. Molecular Brain Research·W PeissnerF Gillardon
Mar 22, 2001·Proceedings of the National Academy of Sciences of the United States of America·A L SirénP Ghezzi
Jul 11, 2001·Apoptosis : an International Journal on Programmed Cell Death·M HolcikR G Korneluk
Aug 6, 2002·Nature Medicine·Michelle L MonjeTheo D Palmer
Oct 31, 2002·The European Journal of Neuroscience·Christine T EkdahlOlle Lindvall
Nov 26, 2002·Annals of Neurology·Jack M ParentDonna M Ferriero
Dec 26, 2002·Neurological Research·Toshiyuki AmanoKiyonobu Ikezaki
Feb 4, 2003·Nature Reviews. Cancer·Andrei V Gudkov, Elena A Komarova
May 15, 2003·Proceedings of the National Academy of Sciences of the United States of America·Serhat ErbayraktarMichael Brines
Jun 19, 2003·Molecular and Cellular Neurosciences·Thorsten TrappDan Lindholm
Oct 4, 2003·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Guodong CaoJun Chen
Nov 15, 2003·Science·Michelle L MonjeTheo D Palmer
Apr 17, 2004·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Nikolaus PlesnilaKlas Blomgren

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Citations

Apr 25, 2007·Apoptosis : an International Journal on Programmed Cell Death·Klas BlomgrenLaurent Groc
Jul 15, 2005·Nature Medicine·Guido Kroemer, Seamus J Martin
Apr 8, 2011·Nature Reviews. Cancer·Patricia S SteegQuentin R Smith
Sep 4, 2008·Proceedings of the National Academy of Sciences of the United States of America·Andrew S NaylorH Georg Kuhn
Oct 1, 2009·PPAR Research·Sriram RamananMike E Robbins
Nov 6, 2012·BMC Medicine·Mustafa KhasrawMichael Berk
Jan 28, 2010·The Journal of Veterinary Medical Science·Myoung-Sub SongChangjong Moon
Sep 7, 2006·Molecular Medicine·Serhat ErbayraktarMichael Brines
Jan 3, 2014·Antioxidants & Redox Signaling·Julie A ReiszCristina M Furdui
Aug 22, 2007·The British Journal of Radiology·W ZhaoM E Robbins
Jan 23, 2016·Molecular Neurobiology·Lianhong YangYamei Tang
Sep 8, 2006·Journal of Neuropathology and Experimental Neurology·Xi Jun HeKunio Doi
May 31, 2011·Best Practice & Research. Clinical Anaesthesiology·Derya SarginHannelore Ehrenreich
May 18, 2010·International Journal of Radiation Oncology, Biology, Physics·James C MarshJulius V Turian
Oct 6, 2009·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Anna BarlindJörgen Isgaard
Mar 15, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Martina BoströmKlas Blomgren
Dec 17, 2008·Journal of Neuroimmunology·Marie KalmKlas Blomgren
Sep 3, 2011·Neuropathology and Applied Neurobiology·E-L von RüdenH Potschka
Mar 15, 2011·The European Journal of Neuroscience·H Georg Kuhn, K Blomgren
Jul 5, 2012·The European Journal of Neuroscience·Karolina RoughtonKlas Blomgren
May 4, 2005·Biochemical and Biophysical Research Communications·Carsten Culmsee, Mark P Mattson
Feb 18, 2006·Neuroscience Letters·Katsuyuki ShiraiTomoaki Shirao
Jun 11, 2014·International Journal of Radiation Biology·Martina BoströmKlas Blomgren
Jul 10, 2014·International Journal of Radiation Biology·Malin BlomstrandKlas Blomgren
Jun 2, 2015·Journal of Neurodevelopmental Disorders·Tine VerreetMohammed Abderrafi Benotmane

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