Irradiation pretreatment enhances the therapeutic efficacy of platelet-membrane-camouflaged antitumor nanoparticles.

Journal of Nanobiotechnology
Yin ChenJunping Wang

Abstract

Cell membrane-based nanocarriers are promising candidates for delivering antitumor agents. The employment of a simple and feasible method to improve the tumor-targeting abilities of these systems is appealing for further application. Herein, we prepared a platelet membrane (PM)-camouflaged antitumor nanoparticle. The effects of irradiation pretreatment on tumor targeting of the nanomaterial and on its antitumor action were evaluated. The biomimetic nanomaterial constructed by indocyanine green, poly(d,l-lactide-co-glycolide), and PM is termed PINPs@PM. A 4-Gy X-ray irradiation increased the proportions of G2/M phase and Caveolin-1 content in 4T1 breast cancer cells, contributing to an endocytic enhancement of PINPs@PM. PINPs@PM produced hyperthermia and reactive oxygen species upon excitation by near-infrared irradiation, which were detrimental to the cytoplasmic lysosome and resulted in cell death. Irradiation pretreatment thus strengthened the antitumor activity of PINPs@PM in vitro. Mice experiments revealed that irradiation enhanced the tumor targeting capability of PINPs@PM in vivo. When the same dose of PINPs@PM was intravenously administered, irradiated mice had a better outcome than did mice without X-ray pretreatment. ...Continue Reading

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Citations

Feb 28, 2021·International Journal of Pharmaceutics·Shalvi Sinai Kunde, Sarika Wairkar
May 21, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Zahid HussainMohammed A S Abourehab
Jul 3, 2021·International Journal of Molecular Sciences·Sandhya ClementEwa M Goldys
Jul 24, 2021·Journal of Nanobiotechnology·Zaihui PengXiaowei Qi

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Methods Mentioned

BETA
X-ray
transmission electron microscopy
electrophoresis
dynamic laser scattering
Flow
flow cytometry

Software Mentioned

FlowJo
SPSS

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