PMID: 6401853Jan 1, 1983Paper

Irregular antibodies: an assessment of routine prenatal screening

Obstetrics and Gynecology
A S SololaJ M Mason

Abstract

In a review of the antenatal-postnatal records of 6062 patients attending the prenatal clinic at a large university perinatal center during 1980, 8.3% of the pregnant patients seen were Rho(D) negative and 91.7% were Rho(D) positive. Through routine antibody screening of all patients, 115 were found to have irregular antibodies which would otherwise not have been detected. Fifteen of these patients were Rho(D) negative, but they would have been included for antibody screening due to their Rho(D) negative status. Of the remaining 100 Rho(D) positive patients, clinically significant antibodies were observed in six patients; however, no maternal morbidity or hemolytic disease of the newborn was reported. Antecedent maternal risk factors for development of irregular antibodies were not sufficiently selective for predicting outcomes of such pregnancies. Furthermore, the only four patients with irregular antibodies requiring blood transfusion were cross-matched without difficulties. Findings suggest that screening all patients for irregular antibodies cannot be justified due to the prohibitive costs involved. However, because of the racially homogeneous population studied, variations in the frequency of red blood cell genotypes betwe...Continue Reading

Related Concepts

Related Feeds

Blood Group Incompatibility

Blood group incompatibility between donor and recipient has been associated with poor transplant outcomes. Discover the latest research on blood group icompatibility here.

Related Papers

American Journal of Obstetrics and Gynecology
V A BarssA Konugres
Transfusion clinique et biologique : journal de la Société française de transfusion sanguine
L MannessierJ Chiaroni
The American Journal of Medical Technology
A E Larsen, C R McIntyre
Medicina
Dalia AdukauskienėKęstutis Rimaitis
© 2021 Meta ULC. All rights reserved