Irreversible aggregation of alternating tetra-block-like amphiphile in water

PloS One
Shota KonnoTaro Toyota

Abstract

As a frontier topic of soft condensed matter physics, irreversible aggregation has drawn attention for a better understanding of the complex behavior of biomaterials. In this study, we have described the synthesis of an artificial amphiphilic molecule, an alternating tetra-block-like amphiphile, which was able to diversify its aggregate structure in water. The aggregated state of its aqueous dispersion was obtained by slow evaporation of the organic solvent at room temperature, and it collapsed irreversibly at ~ 50°C. By using a cryo-transmission electron microscope and a differential scanning calorimeter, it was revealed that two types of molecular nanostructures were formed and developed into submicro- and micrometer-sized fibrils in the aggregated material.

References

Jun 20, 1990·Journal of Molecular Biology·R HendersonK H Downing
Sep 1, 1985·Physical Review. B, Condensed Matter·G S Grest, D J Srolovitz
Apr 6, 2002·Science·K N PhamW C K Poon
Jan 1, 1963·Journal of Pharmaceutical Sciences·W I HIGUCHIA P LEMBERGER
Oct 7, 2004·Chemical Communications : Chem Comm·Olli Ikkala, Gerrit ten Brinke
May 18, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Chi-Ying LeeDavid G Castner
Oct 1, 2005·Nature Materials·Raffaele MezzengaMartin Michel
Sep 22, 2010·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Renata PavišićMario Cindrić
Jul 23, 2011·Angewandte Chemie·Anne-Laure FameauJean-Paul Douliez
Nov 19, 2011·Chemistry : a European Journal·Anton KnyazevStéphane Campidelli
Mar 5, 2015·Chemical Society Reviews·Christina RestGustavo Fernández
Jul 22, 2015·Physical Review Letters·C Patrick RoyallHajime Tanaka
Mar 23, 2017·Carbohydrate Polymers·Jintao HeGuangzhe Piao
Mar 30, 2017·Accounts of Chemical Research·Rongchun ZhangAyyalusamy Ramamoorthy
Jul 18, 2017·Angewandte Chemie·Thirupathi RavulaAyyalusamy Ramamoorthy
Jan 14, 2018·Nature Communications·Yunlong ZhouNicholas A Kotov

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Methods Mentioned

BETA
column chromatography
X-ray
optical microscopy

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