Irreversible change in the T1 temperature dependence with thermal dose using the proton resonance frequency-T1 technique.

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Mahamadou DiakiteDennis L Parker

Abstract

Denaturation of macromolecules within the tissues is believed to be the major factor contributing to the damage of tissues upon hyperthermia. As a result, the value of the spin-lattice relaxation time T1 of the tissue water, which is related to the translational and rotational rates of water, represents an intrinsic probe for investigating structural changes in tissues at high temperature. Therefore, the goal of this work is to investigate whether the simultaneous measurement of temperature and T1 using a hybrid proton resonance frequency (PRF)-T1 measurement technique can be used to detect irreversible changes in T1 that might be indicative of tissue damage. A new hybrid PRF-T1 sequence was implemented based on the variable flip angle driven-equilibrium single-pulse observation (DESPOT)1 method from a standard three dimensional segmented echo-planar imaging sequence by alternating two flip angles from measurement to measurement. The structural changes of the heated tissue volumes were analyzed based on the derived T1 values and the corresponding PRF temperatures. Using the hybrid PRF-T1 technique, we demonstrate that the change of spin lattice relaxation time T1 is reversible with temperature for low thermal dose (thermal dose...Continue Reading

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Citations

Sep 6, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Dennis L ParkerJ Rock Hadley
Jan 18, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Bryant T SvedinDennis L Parker
Feb 23, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Thibaut L FallerEmeline J Ribot
May 15, 2020·Nanotechnology·Yapeng ZhangWenzhong Liu
Nov 22, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Nick ToddDennis L Parker
Jul 2, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Le ZhangHolden H Wu
Feb 26, 2019·Progress in Nuclear Magnetic Resonance Spectroscopy·Henrik Odéen, Dennis L Parker

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