Irreversible electroporation attenuates neointimal formation after angioplasty

IEEE Transactions on Bio-medical Engineering
Elad MaorBoris Rubinsky

Abstract

Restenosis following coronary angioplasty represents a major clinical problem. Irreversible electroporation (IRE) is a nonthermal, nonpharmacological cell ablation method. IRE utilizes a sequence of electrical pulses that produce permanent damage to tissue within a few seconds. The left carotid arteries of eight rats underwent in vivo intimal damage using two Fogarty angioplasty catheters. The procedure was immediately followed by IRE ablation in four rats, while the remaining four were used as the control group. The IRE ablation was performed using a sequence of ten dc pulses of 3800 V/cm, 100 micros each, at a frequency of ten pulses per second, applied across the blood vessel between two parallel electrodes. The electrical conductance of the treated tissue was measured during the electroporation to provide real-time feedback of the process. Left carotid arteries were excised and fixated after a 28-day follow-up period. Neointimal formation was evaluated histologically. The use of IRE was successful in three out of four animals in a way that is consistent with the measurements of blood vessel electrical properties. The integrity of the endothelial layer was recovered in the IRE-treated animals, compared with control. Successf...Continue Reading

References

Jul 1, 1994·The Tohoku Journal of Experimental Medicine·T J Liao, H Nishikawa
Sep 1, 1994·The British Journal of Surgery·M G Davies, P O Hagen
Feb 29, 2000·Journal of Vascular and Interventional Radiology : JVIR·M NarayanaswamyK Kandarpa
Sep 7, 2000·Circulation·M R WardC Borst
Sep 23, 2000·Nature·A J Lusis
Oct 12, 2000·JAMA : the Journal of the American Medical Association·J Al SuwaidiD R Holmes
Feb 15, 2001·The New England Journal of Medicine·M B LeonR E Kuntz
Nov 17, 2001·Heart·R MansfieldJ McEwan
Apr 11, 2002·IEEE Transactions on Bio-medical Engineering·Rafael V DavalosDavid M Otten
Jun 7, 2002·The New England Journal of Medicine·Marie-Claude MoriceUNKNOWN RAVEL Study Group. Randomized Study with the Sirolimus-Coated Bx Velocity Balloon-Expandable Stent in the Treatment of Patie
Oct 3, 2002·British Journal of Pharmacology·V Margaret JacksonTom C Cunnane
Dec 31, 2002·Journal of the American College of Cardiology·Ick-Mo ChungThomas N Wight
Mar 15, 2003·Physiological Measurement·Carl A ShiffmanSeward B Rutkove
Oct 3, 2003·The New England Journal of Medicine·Jeffrey W MosesUNKNOWN SIRIUS Investigators
Jan 16, 2004·The New England Journal of Medicine·Gregg W StoneUNKNOWN TAXUS-IV Investigators
Nov 5, 2004·Journal of Vascular and Interventional Radiology : JVIR·Mario FavaJames D Joye
Mar 18, 2005·Annals of Biomedical Engineering·R V DavalosB Rubinsky
Mar 29, 2005·Biophysical Journal·Mojca PavlinDamijan Miklavcic
Aug 18, 2005·Journal of Vascular and Interventional Radiology : JVIR·John LairdJames D Joye
Aug 27, 2005·IEEE Transactions on Bio-medical Engineering·Natasa PavseljDamijan Miklavcic
Nov 19, 2005·Technology in Cancer Research & Treatment·Liron MillerBoris Rubinsky
Mar 2, 2006·Toxicologic Pathology·Arturo G Touchard, Robert S Schwartz
Jul 13, 2006·IEEE Transactions on Bio-medical Engineering·Jon F EddBoris Rubinsky
Aug 26, 2006·Medical & Biological Engineering & Computing·C ChenJ A Evans
Dec 5, 2006·Bioelectrochemistry·Antoni Ivorra, Boris Rubinsky
Dec 23, 2006·Journal of Vascular and Interventional Radiology : JVIR·Wai-ki YiuBauer E Sumpio
Jan 5, 2007·Vascular and Endovascular Surgery·Russell H SamsonScott Ames
Jan 30, 2007·Bioelectrochemistry·David CukjatiLluis M Mir
Feb 7, 2007·Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society·Raphael C Lee, Florin Despa
Feb 14, 2007·The New England Journal of Medicine·Bo LagerqvistUNKNOWN SCAAR Study Group
Aug 3, 2007·Technology in Cancer Research & Treatment·Boris Rubinsky
Aug 3, 2007·Technology in Cancer Research & Treatment·Elad MaorBoris Rubinsky
Nov 9, 2007·PloS One·Bassim Al-SakereLluis M Mir

❮ Previous
Next ❯

Citations

Aug 17, 2010·Cardiovascular and Interventional Radiology·Maciej PechUwe-Bernd Liehr
Dec 22, 2009·Integrative Biology : Quantitative Biosciences From Nano to Macro·Won Gu LeeAli Khademhosseini
Jul 31, 2009·Journal of Biomechanical Engineering·Charlotte Daniels, Boris Rubinsky
May 13, 2010·Journal of Biomechanical Engineering·Elad Maor, Boris Rubinsky
Sep 8, 2010·Journal of Biomechanical Engineering·Mary PhillipsBoris Rubinsky
Mar 2, 2010·Biomedical Engineering Online·Alex Golberg, Boris Rubinsky
Feb 24, 2011·AJR. American Journal of Roentgenology·Ajita DeodharStephen B Solomon
Apr 1, 2014·Biomedical Microdevices·Tomás García-SánchezRamon Bragós
Mar 17, 2016·Gastroenterology Research and Practice·Salvatore PaiellaClaudio Bassi
Oct 12, 2010·Journal of Vascular and Interventional Radiology : JVIR·Elad MaorBoris Rubinsky
Aug 4, 2011·Bioelectromagnetics·Marie Breton, Lluis M Mir
Feb 11, 2009·IEEE Transactions on Bio-medical Engineering·Gorazd PuciharTadej Kotnik
Aug 2, 2014·IET Nanobiotechnology·Vitalij NovickijSvetlana Markovskaja
Mar 30, 2018·Expert Review of Cardiovascular Therapy·Alan SugrueSamuel Asirvatham
Jul 31, 2009·Physics in Medicine and Biology·Yair GranotBoris Rubinsky
Feb 23, 2020·PloS One·Alan SugrueChristopher J McLeod
Dec 14, 2016·World Journal of Gastroenterology : WJG·Mirko D'OnofrioClaudio Bassi
Oct 5, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Li TianMarites P Melancon

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.