Abstract
Irreversible electroporation (IRE) is a new ablation modality. Our purpose was to describe the effectiveness and the safety of the treatment and to evaluate the magnetic resonance imaging (MRI), computed tomography (CT) and contrast-enhanced ultrasound (CEUS) diagnostic accuracy in HCC patients treated with IRE at 1-, 3-, and 6-month follow-up. In an 18-month period, we treated 24 HCC lesions in 20 patients unfit for surgery. MRI, CT and CEUS were performed before and one, 3 and 6 month after IRE. We employed the liver-specific contrast medium Primovist (gadolinium ethoxybenzyl dimeglumine) in MRI. After IRE the lesions were classified as responders or non-responders to the treatment according to the mRECIST and the complications were recorded. We evaluated the size, shape, signal intensity (T1-W, T2-W, and DWI) in MRI, dynamic contrast enhancement pattern for CEUS, CT and MRI and signal behavior during the liver-specific phase for MRI. According to mRECIST, at 1 month MRI and CEUS showed a complete response (CR) in 91.7% of cases (22/24) tumors, while there was partial response (PR) in the remaining 2/24 (8.3%) treated nodules; in CT study all ablated zone appeared as necrotic (CR 100%). The residual viable tumor in MRI and in...Continue Reading
References
Jan 1, 1981·Cancer·A B MillerA Winkler
Sep 6, 2000·Annals of Surgery·S A CurleyP Vallone
Mar 17, 2004·Annals of Surgery·Steven A CurleyFrancesco Izzo
Jun 11, 2005·Journal of Vascular and Interventional Radiology : JVIR·S Nahum GoldbergUNKNOWN Society of Interventional Radiology Technology Assessment Committee
Oct 16, 2007·Cancer Detection and Prevention·Robert M EiselePeter Neuhaus
Jan 10, 2008·Journal of Magnetic Resonance Imaging : JMRI·Azzam A KhankanHironobu Nakamura
Dec 23, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E A EisenhauerJ Verweij
Feb 4, 2010·Cancer Research·Yang GuoAndrew C Larson
Feb 23, 2010·Seminars in Liver Disease·Riccardo Lencioni, Josep M Llovet
Jul 27, 2010·Radiology·Yue ZhangAndrew C Larson
Feb 24, 2011·AJR. American Journal of Roentgenology·Ajita DeodharStephen B Solomon
Mar 2, 2011·Journal of Surgical Oncology·Matthew BowerRobert Martin
Mar 5, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jordi BruixUNKNOWN American Association for the Study of Liver Diseases
Mar 29, 2011·Journal of Vascular and Interventional Radiology : JVIR·Kenneth R ThomsonAndrew Haydon
Apr 2, 2011·Cardiovascular and Interventional Radiology·Ajita DeodharStephen B Solomon
Sep 13, 2011·Abdominal Imaging·Carmen AyusoAngeles García-Criado
Dec 6, 2011·Journal of Vascular and Interventional Radiology : JVIR·Edward W LeeStephen T Kee
Dec 23, 2011·Radiology·Riccardo Lencioni, Laura Crocetti
Mar 20, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·UNKNOWN European Association for Study of Liver, UNKNOWN European Organisation for Research and Treatment of Cancer
Dec 13, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Emmanuel TsochatzisAndrew K Burroughs
Feb 2, 2013·Technology in Cancer Research & Treatment·W CheungK R Thomson
Mar 16, 2013·Journal of Computer Assisted Tomography·Young Joon LeeCharles Lassman
Jul 13, 2013·Radiology·Eliel Ben-DavidS Nahum Goldberg
Oct 16, 2013·Radiology·Liat AppelbaumS Nahum Goldberg
Nov 14, 2013·PloS One·Prejesh PhilipsRobert C G Martin
Nov 23, 2013·Journal of Vascular and Interventional Radiology : JVIR·Mikhail T SilkStephen B Solomon
Dec 11, 2013·Gastroenterology Research and Practice·Vincenza GranataAntonella Petrillo
Feb 14, 2014·Acta Radiologica·Orlando CatalanoAntonella Petrillo
Feb 11, 2015·World Journal of Gastroenterology : WJG·Wei YangMin-Hua Chen
Apr 24, 2015·AJR. American Journal of Roentgenology·Vincenza GranataAntonella Petrillo
Jun 3, 2015·Japanese Journal of Radiology·Katsutoshi SugimotoIkuo Nakamura
Citations
Jan 23, 2017·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·P FrühlingA Norén
Jun 21, 2017·PloS One·Vincenza GranataAntonella Petrillo
Dec 19, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Matteo FiginiZhuoli Zhang
Sep 9, 2017·Oncotarget·Vincenza GranataAntonella Petrillo
Dec 24, 2016·Oncotarget·Guo TianWeilin Wang
May 29, 2020·Radiology and Oncology·Vincenza GranataAntonella Petrillo
Jul 22, 2017·The British Journal of Radiology·Vincenza GranataAntonella Petrillo
May 4, 2017·Infectious Agents and Cancer·Vincenza GranataAntonella Petrillo
Jul 14, 2020·World Journal of Gastroenterology : WJG·Zhen-Guo LiuZhi-Gang Ren
Aug 3, 2017·World Journal of Gastroenterology : WJG·Vincenza GranataAntonella Petrillo
May 16, 2019·Abdominal Radiology·Vincenza GranataAntonella Petrillo
Jul 1, 2020·The Journal of International Medical Research·Vincenza GranataAntonella Petrillo
Nov 25, 2020·World Journal of Surgical Oncology·Linyu ZhouTian'an Jiang
Nov 17, 2020·Clinical and Experimental Gastroenterology·Anna J ShangguanZhuoli Zhang
Dec 18, 2020·Frontiers in Oncology·Vincenza GranataFrancesco Izzo
Oct 15, 2020·Cardiovascular and Interventional Radiology·E FreemanS K Roberts
Feb 28, 2021·European Radiology·Pankaj GuptaNaveen Kalra
Apr 4, 2021·Journal of Clinical Medicine·Francesco IzzoRaffaele Palaia
Apr 4, 2021·International Journal of Environmental Research and Public Health·Vincenza GranataFrancesco Izzo
Jun 25, 2021·World Journal of Gastroenterology : WJG·Vincenza GranataFrancesco Izzo
Dec 1, 2019·Bioelectricity·Kenneth N Aycock, Rafael V Davalos