Irreversible marrow aplasia after single course of 2-chlorodeoxyadenosine for hairy cell leukaemia preceding by A pandemic 2009-H1N1-associated pneumonia.

Medical Oncology
Grzegorz HelbigSławomira Kyrcz-Krzemien

Abstract

Hairy cell leukaemia (HCL) is a rare, indolent lymphoproliferative disorder characterized by varying degrees of cytopenias and the presence of malignant B cells with cytoplasmic projections. Cladribine (2-chlorodeoxyadenosine, 2-CdA) is an adenosine deaminase-resistant purine analogue and has been shown to be very effective as a first-line therapeutic option for HCL. The therapy with 2-CdA is found to be well tolerated with a paucity of toxicity. The common side effects include immunosuppression and reversible myelosuppression. We report a HCL patient with A pandemic 2009-H1N1-associated pneumonia who fully recovered after oseltamivir and antibiotics. The subsequent treatment with single 5-day course of 2-CdA resulted in persistent marrow aplasia with fatal systemic aspergillosis.

References

Nov 1, 1978·Annals of Internal Medicine·H M GolombD W Golde
Apr 19, 1990·The New England Journal of Medicine·L D PiroE Beutler
Sep 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B D Cheson
Jun 1, 1997·Clinical and Laboratory Haematology·R J FrewinA G Smith
Apr 8, 1998·British Journal of Haematology·J A OrchardD G Oscier
Jul 29, 1998·Clinical and Laboratory Haematology·E Psiachou-Leonard, B J Bain
Apr 28, 2001·British Journal of Haematology·T RobakA B Skotnicki
Oct 22, 2009·Blood·Michael R Grever
Mar 30, 2010·British Journal of Haematology·Cristian LaunesJesús Estella

❮ Previous
Next ❯

Citations

Oct 6, 2016·Open Forum Infectious Diseases·Nancy F Crum-Cianflone
Oct 10, 2018·Current Opinion in Infectious Diseases·Lore VanderbekeJoost Wauters

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Aspergillosis

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

Aspergillosis (ASM)

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.