PMID: 16518129Mar 7, 2006Paper

Irreversible neurological worsening following high-dose corticosteroids in advanced progressive multiple sclerosis

Clinical Neuropharmacology
Marcus Koch, Jacques De Keyser

Abstract

A course of high-dose corticosteroids has been shown to hasten recovery from a relapse of multiple sclerosis (MS). Some patients with progressive MS ask for a course with corticosteroids outside a relapse, hoping to gain some functional improvement. To describe 4 patients with advanced progressive MS who experienced worsening of disability after treatment with high-dose corticosteroids. All 4 patients had moderate to severe disability and asked for corticosteroid treatment because they were slowly progressing. None of them had a relapse. All experienced improvement by the end of the treatment course. One or 2 days after discontinuation of treatment, however, they deteriorated clinically and became more disabled than before treatment. The use of high-dose corticosteroid therapy in progressive forms of MS outside relapses can be detrimental and worsen disability.

References

Apr 29, 1998·Brain : a Journal of Neurology·L FuD L Arnold
Sep 5, 1998·Journal of Neurology, Neurosurgery, and Psychiatry·H L TremlettC M Wiles
Mar 30, 2005·Multiple Sclerosis : Clinical and Laboratory Research·Robert J FoxRichard A Rudick
Jul 27, 2005·Multiple Sclerosis : Clinical and Laboratory Research·J S Sloka, M Stefanelli

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Citations

Sep 22, 2007·Lancet Neurology·David H Miller, Siobhan M Leary

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