Irreversible Photoreceptors and RPE Cells Damage by Intravenous Sodium Iodate in Mice Is Related to Macrophage Accumulation

Investigative Ophthalmology & Visual Science
Mayu MoriguchiHideaki Hara

Abstract

To determine the mechanism causing degeneration of the retinal pigment epithelium (RPE) and photoreceptors in mice after an intravenous injection of sodium iodate (NaIO3). The time-dependent changes in NaIO3-induced retinal degeneration were determined by analyzing the retinal morphology by optical coherence tomographic (OCT) images, histological sections of the retina, physiology of the retina by electroretinography (ERG), and retinal blood flow by laser speckle flowgraphy. In addition, the expression of the genes associated with age-related macular degeneration in humans was assessed in the NaIO3-treated mice by RT-PCR. We also investigated whether macrophages were involved in the NaIO3-induced retinal degeneration. The intravenous injection of 20 mg/kg NaIO3 altered the morphology of the RPE cells and the ERGs transiently. With 40 mg/kg of NaIO3, the degeneration of the RPE cells was still present at 28 days. Aggregated melanin granules were surrounded by zonula occludens protein 1 (ZO-1)-positive cells. In addition, 40 mg/kg of NaIO3 led to a reduction in the amplitudes of the a- and b-waves of the dark-adapted ERGs. Histological studies showed that macrophages had infiltrated the retina and were present around the altered ...Continue Reading

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Citations

Dec 26, 2018·Oxidative Medicine and Cellular Longevity·Weiwei DuWei He
Feb 23, 2020·Cell Reports·Kelly MulfaulSarah L Doyle
Dec 18, 2020·Frontiers in Cell and Developmental Biology·Yao Tong, Shusheng Wang
Jul 13, 2021·Translational Vision Science & Technology·Nan ZhangJohn M Nickerson
Jul 11, 2021·Experimental Eye Research·Zhanyu NiuLan Gao
Nov 10, 2021·Translational Vision Science & Technology·Hideo KohnoTadashi Nakano

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