PMID: 20650042Jul 24, 2010Paper

Irreversible sensorineural hearing loss: an unusual side effect of non-steroidal anti-inflammatory drugs

International Journal of Clinical Pharmacology and Therapeutics
S AhmadM Karim

Abstract

Non-steroidal anti-inflammatory drugs are known to have a number of potential side effects. Here we report a case demonstrating an uncommon complication, irreversible sensorineural deafness. A 41-year-old man with pre-existing cardiac and renal dysfunction (for which his regular medications included furosemide) presumed secondary to a viral myocarditis developed acute sensorineural hearing loss 5 days after commencing treatment with indomethacin 25 mg tds for acute gout. His hearing loss was preceded by the development of tinnitus and failed to recover. Permanent deafness is a rare but serious side effect of NSAIDs. Tinnitus developing in patients on these agents should be regarded as a potential warning sign of impending irreversible ototoxicity.

Citations

Jul 28, 2011·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Margarita C Currás-Collazo
Jan 10, 2012·Chemical & Pharmaceutical Bulletin·Fatma Abd El-Fattah RagabYassin Mohammed Nissan
Jan 16, 2013·Biotechnology Advances·Amit Kumar MittalUttam Chand Banerjee
Jan 7, 2015·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Meghann E KyleJennifer J Shin
Nov 4, 2017·Clinical Pediatrics·Maria Carratola GrantJ Lindhe Guarisco
Jan 1, 2021·BioMed Research International·Fuda XieJiangyong Gu

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