PMID: 6401430Feb 1, 1983Paper

Irreversible visual loss in Waldenström's macroglobulinaemia

The British Journal of Ophthalmology
E L ThomasA Patz

Abstract

A patient with Waldenström's macroglobulinaemia presented with visual reduction in both eyes. The funduscopic and angiographic demonstrations of venous engorgement ('string of sausages'), retinal haemorrhages at all levels, retinal and disc oedema, and serous detachment of the maculas were consistent with this diagnosis. The cryoprecipitation of the immunoglobulin at a temperature slightly below body temperature precluded routine blood studies and plasmapheresis. Plasmapheresis was ultimately performed without difficulty with the patient and equipment at 88 degrees F (31 degrees C). Despite marked improvement in the funduscopic and angiographic appearance of the retina, perifoveal capillary nonperfusion and serous elevation of the macula persisted. Even when the maculas flattened in both eyes, no visual recovery occurred. Early diagnosis, even on a clinical basis when laboratory studies cannot be performed, and early plasmapheresis to reduce serum viscosity are warranted to prevent intravascular occlusion in the perifoveal capillary bed, deposition of immunoglobulin in the retina, and transudation in the subretinal space.

References

Jun 1, 1976·The British Journal of Ophthalmology·G K AsdourianM F Goldberg
May 1, 1968·American Journal of Ophthalmology·E S RosenT W Warnes
Apr 1, 1980·Archives of Ophthalmology·A H FreidmanS N Thung
Jun 1, 1959·American Journal of Clinical Pathology·M R PACHTERJ P TRUANT

❮ Previous
Next ❯

Citations

Jun 17, 2000·Ophthalmology·A C HoJ Wong
Mar 26, 2002·Journal of Experimental Psychology. Learning, Memory, and Cognition·R Brooke Lea, Elizabeth J Mulligan
Jan 1, 1995·The British Journal of Ophthalmology·T H WilliamsonG M Baxter
Aug 1, 1997·The British Journal of Ophthalmology·T H Williamson
Sep 6, 2012·Case Reports in Ophthalmology·Aurélie BrollySalomon Yves Cohen
Dec 8, 2011·Blood·Marvin J Stone, Steven A Bogen
Jul 26, 2014·Emergency Medicine Clinics of North America·Umar A KhanMichael T McCurdy
Jun 1, 1985·Blut·H H EulerH Löffler
Oct 29, 2002·Leukemia & Lymphoma·Morie A Gertz
Feb 1, 1991·Journal of Youth and Adolescence·K M GalottiM C Farmer
Jul 27, 2005·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Andrew F PilonLeonard V Messner
Apr 15, 2015·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Krishnendu RoySomedeb Ball
Jan 22, 2020·Leukemia & Lymphoma·Iuliana Vaxman, Morie Gertz
Feb 17, 2017·Retina·Frederick R BurgessCharles C Wykoff
Apr 23, 2015·Retina·Sripathi KamathSandeep Randhawa
Dec 17, 2014·Cancer Control : Journal of the Moffitt Cancer Center·Laura S Connelly-Smith, Michael L Linenberger
May 17, 2017·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·V C MüllerN Eter
Jun 2, 2005·American Journal of Hematology·Morie A Gertz
Jul 19, 2019·Progress in Retinal and Eye Research·Thomas J van RijssenCamiel J F Boon
Feb 25, 2021·The New England Journal of Medicine·Marc A BouffardLucas R Massoth
May 15, 2020·Progress in Retinal and Eye Research·Rebecca KayeAndrew Lotery
Mar 16, 2021·Progress in Retinal and Eye Research·Elon H C van Dijk, Camiel J F Boon
Sep 1, 1987·Baillière's Clinical Haematology·T Somer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.