Irrigation of port sites: prevention of port site metastases?

Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a
Philippe WittichH J Bonjer

Abstract

Port site metastases can occur when free viable tumor cells implant at trocar wounds. Irrigation of port sites with cytotoxic agents has been suggested to prevent port site metastases. The objective of this study is to assess whether tumor growth at port sites can be reduced by irrigation of these port sites. WAG rats were insufflated with CO(2) for 20 minutes and 5 x 10(5) CC531 tumor cells were injected intraperitoneally. Port sites were irrigated after completion of the pneumoperitoneum with povidone-iodine, a mixture of taurolidine and heparin, or sodium chloride. Controls did not undergo any irrigation of port sites. In experiment 1, all 16 rats had all 4 irrigation modalities. In experiment 2, four groups of 20 rats had one type of irrigation on two trocar wounds. Tumor growth was evaluated 4 weeks after the procedure. No difference in tumor growth at trocar wounds was found between any type of irrigation and controls in both experiments. In this experimental model, no beneficial or adverse effects of irrigation of port sites could be shown.

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Citations

May 27, 2005·The Journal of Surgical Research·Chris BraumannChristoph A Jacobi
Jul 16, 2008·Journal of Endourology·Michael K EngKevin C Zorn
Jan 10, 2013·Journal of Endourology·Joseph B SongR Sherburne Figenshau
Nov 17, 2012·World Journal of Gastroenterology : WJG·Quan-Da LiuNing-Xin Zhou
Apr 1, 2006·Journal de gynécologie, obstétrique et biologie de la reproduction·M CanisG Mage
Mar 18, 2008·Urology·Octavio A Castillo, Gonzalo Vitagliano
May 19, 2006·Surgical Innovation·Marc ZereyB Todd Heniford

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