Irritable bowel syndrome and gastroesophageal reflux disease in primary care: is there a link?

Digestive Diseases and Sciences
A RuigómezLuis Alberto García Rodríguez

Abstract

Population-based studies have shown that gastroesophageal reflux disease (GERD) and irritable bowel syndrome (IBS) coexist more commonly than expected by chance. We aimed to investigate the relationship between GERD and IBS in primary care. The General Practice Research Database was used to identify patients with a first diagnosis of GERD (n=6,421) or IBS (n=2,932). Patients were followed up for 12 months after diagnosis to investigate the incidence of IBS among GERD patients and GERD among IBS patients. The relative risk (RR) of developing IBS was 3.5 (95% CI: 2.3-5.4) in the GERD cohort compared with the comparison cohort. The RR of developing GERD was 2.8 (95% CI: 1.7-4.9) in the IBS cohort compared with the comparison cohort. A first diagnosis of either IBS or GERD significantly increases the risk of a subsequent diagnosis of the other condition.

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Citations

Feb 9, 2012·International Journal of Health Geographics·Ewa GrodzinskyAshild Olsen Faresjö
Mar 12, 2010·World Journal of Gastroenterology : WJG·Shadi-Sadeghi YarandiReza Malekzadeh
Jul 31, 2012·ISRN Gastroenterology·Sylvester Chuks Nwokediuko
Feb 8, 2014·Gastroenterology Clinics of North America·Joel H Rubenstein, Joan W Chen
Feb 23, 2013·ISRN Gastroenterology·Maria José Solana GarcíaCésar Sánchez Sánchez

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