Irritable bowel syndrome and the elusive mast cells

The American Journal of Gastroenterology
Theoharis C TheoharidesJan D Huizinga

Abstract

Irritable bowel syndrome (IBS) is the most common condition seen by gastroenterologists. It presents with alternating symptoms of bowel dysfunction that often worsens with stress. The cause of these symptoms eludes investigators and many attempts have been made to discover an underlying pathology. This is a daunting task since symptoms come and go, and change characteristics. Furthermore, the pathology of IBS is unlikely to be identical in all patients. In addition, all symptoms and all features studied thus far have a strong overlap with healthy volunteers. Elsewhere in this issue, Braak et al. report a well-designed clinical investigation in patients with IBS and come to the conclusion that IBS is not characterized by mast cell or other immune cell proliferation, but by immune dysregulation in the colon. Is this the final answer?

References

May 20, 1982·Nature·T C TheoharidesP W Askenase
Jun 11, 2002·Gastroenterology·Vinton S ChadwickIan Wilson
Dec 31, 2003·Journal of Neuroimmunology·Theoharis C Theoharides, David E Cochrane
Jun 10, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jing CaoTheoharis C Theoharides
May 15, 2007·Immunological Reviews·Theoharis C TheoharidesDimitris Kalogeromitros
May 19, 2007·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·X-Y WangJ D Huizinga
Jul 17, 2008·Current Gastroenterology Reports·Trinh T TruongLin Chang
Jul 17, 2008·Current Gastroenterology Reports·Roberto De Giorgio, Giovanni Barbara
Jun 11, 2010·Journal of Neurogastroenterology and Motility·Oh Young Lee
Oct 5, 2010·Nature Reviews. Gastroenterology & Hepatology·Sarah Khan, Lin Chang
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Apr 11, 2012·The American Journal of Gastroenterology·Breg BraakGuy E Boeckxstaens

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Citations

Jan 15, 2016·The Journal of Pharmacology and Experimental Therapeutics·Irene TsilioniTheoharis C Theoharides
Jan 13, 2016·Journal of Neurogastroenterology and Motility·Lei ZhangXiaohua Hou
Jan 18, 2017·Experimental Dermatology·Theoharis C Theoharides
Nov 22, 2013·Current Opinion in Gastroenterology·Vineet S Gudsoorkar, Eamonn M M Quigley
Jan 24, 2018·World Journal of Gastroenterology : WJG·De-Rong LiuShu-Kun Yao
Dec 2, 2020·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Hirsh D KomarowDean D Metcalfe

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