Irritancy ranking of 31 cleansers in the Indian market in a 24-h patch test

International Journal of Cosmetic Science
C LakshmiA C Mathew

Abstract

Cleansing trends promise freshness, sensory and health benefits but may also be accompanied by an increase in soap-induced skin irritation. The aim of this study was to evaluate the irritant effect of 31 cleansers (28 bar soaps and 3 liquid cleansers) available in the Indian market. Eight percent w/v solutions of the soaps/cleansers were made and 30 microL of each of the solutions were applied to Finn chambers and occluded for 24 h along with distilled water (negative control) and 20% sodium dodecyl sulphate (SDS) as positive control. The sites were graded for erythema and scaling 30 min after removing the patches. The pH of each of the soap solutions was determined. Mean with SD and ANOVA (F-value) was computed separately for each soap/cleanser with respect to the two parameters, erythema and scaling. The total of the means for both the parameters, erythema and scaling was also computed. The cleansers were listed based on this total from the least irritant to the most irritant. The differences between soaps (F-value) was significant for erythema and scaling [erythema = 4.106 (P = 0.000); scaling = 6.006 (P = 0.000)]. Cetaphil cleansing lotion had the lowest erythema score of 0.25. Lowest scaling score of zero was recorded for ...Continue Reading

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Citations

May 17, 2011·Indian Journal of Dermatology·Partha Mukhopadhyay
May 7, 2010·Indian Journal of Dermatology, Venereology and Leprology·A J AustoriaA C Mathew
Dec 20, 2017·Dermatitis : Contact, Atopic, Occupational, Drug·Erin M WarshawKathryn A Zug
Jan 5, 2019·Home Healthcare Now·Jill Brennan-Cook, Rachel L Turner
Jun 27, 2021·Jornal de pediatria·Larissa Habib Mendonça Gois TopanKerstin Taniguchi Abagge
Jan 27, 2010·Pediatrics·Ivan V LitvinovBernard A Cohen

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