Irritant and co-carcinogenic diterpene esters from the latex of Euphorbia cauducifolia L

Journal of Asian Natural Products Research
Imam Bakhsh Baloch, Musa Kaleem Baloch

Abstract

Ten (1-10) irritant and mild co-carcinogenic diterpene esters were isolated from the latex of Euphorbia cauducifolia L. using bioassay-guided countercurrent distribution and other chromatographic techniques. The isolated compounds were characterized on the basis of spectroscopic results and mass measurements. As an outcome, the ingenane-type esters were established with the following structures: 3-O-angeloyl-17-O-palmatoylingenol (1), 3-O-palmatoyl-5-O-angeloylingenol (2), 5-O-angeloyl-17-O-palmatoylingenol (3), 3-O-angeloyl-5-O-palmatoylingenol (4), 17-O-(2Z,4E,6Z)-2,4,6-tetradecatrienoyl-20-O-palmatoylingenol (5), 5-O-angeloyl-17-O-benzoylingenol (6), 5-O-angeloyl-17,20-diacetoxyingenol (7), 3-O-angeloyl-17-O-benzoyl-20-acetoxyingenol (8), 3-acetoxy-5-O-angeloyl-17-O-benzoylingenol (9), and 5-O-angeloyl-3,17,20-triacetoxyingenol (10). Their biological screening revealed that they are moderate irritants, and low to moderate tumor promoters compared to TPA, but hardly showed any solitary carcinogenic activity. The isolated esters represent new compounds and were not reported before from any source.

References

Sep 24, 2005·Journal of Asian Natural Products Research·Jie KangDe-Quan Yu
Aug 2, 2006·Planta medica·Imam Bakhsh BalochQazi Najam Saqib
May 22, 2007·European Journal of Medicinal Chemistry·Imam Bakhsh BalochQazi Najam us Saqib
Nov 3, 2007·Phytochemistry·Zhi-Qiang LuDe-An Guo
Nov 26, 2008·Journal of Asian Natural Products Research·Ying-Kun QiuFeng Dong
Nov 26, 2008·Journal of Asian Natural Products Research·Shahnaz SultanaPriyanka Bagri
Nov 26, 2008·Journal of Asian Natural Products Research·Nighat NazirGhulam Nabi Qazi
Nov 26, 2008·Journal of Asian Natural Products Research·Jing-Yuan MaHai-Yan Wang
Nov 26, 2008·Journal of Asian Natural Products Research·Shi-Xiu FengXiao-Yi Wei
Apr 21, 2009·European Journal of Medicinal Chemistry·Imam Bakhsh BalochAhmad Khan Baloch

❮ Previous
Next ❯

Citations

Nov 10, 2010·Journal of Asian Natural Products Research·Imam Bakhsh Baloch, Musa Kaleem Baloch
Oct 20, 2011·Natural Product Research·Imam Bakhsh Baloch, Musa Kaleem Baloch
Jul 23, 2016·Journal of Natural Products·Bin ZhouJian-Min Yue
Apr 19, 2018·Journal of Asian Natural Products Research·Sheng-Nan ZhangQin-Gang Tan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.