Irritant-induced asthma in the workplace

Current Allergy and Asthma Reports
S M Tarlo

Abstract

Irritant-induced asthma in the workplace has been the focus of several articles in the past few years, and reviewed here. A clinical case definition is most readily associated with a single acute/accidental exposure to a presumed high concentration of an agent or agents expected to be irritant to the airways, as was initially reported with the subgroup Reactive Airways Dysfunction Syndrome (RADS). When most but not all criteria for RADS are met, then a diagnosis of irritant-induced asthma may also be considered to be "more probable than not". However, in addition, there is evolving understanding from epidemiological studies that chronic exposures may be associated with an increased risk of developing asthma. Despite this recognition, the mechanisms and clinical case definitions of work-related asthma that might be caused by chronic exposures to irritants (vs. new-onset asthma that begins coincidentally to work exposures), remain unclear at present.

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Citations

Dec 10, 2015·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Enrico CasimirriPiera Boschetto
Apr 4, 2015·The European Respiratory Journal·Orianne DumasRachel Nadif
Feb 26, 2016·Current Opinion in Allergy and Clinical Immunology·Orianne Dumas, Nicole Le Moual
Nov 14, 2017·The Medical Journal of Australia·Ryan F Hoy, Fraser Brims
Apr 12, 2019·Respiratory Research·Joseph JudeReynold A Panettieri
Sep 3, 2020·Medicina·Diego A Arteaga-BadilloEduardo Madrigal-Santillán
Feb 26, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Orianne DumasNicole Le Moual
Apr 9, 2021·Regulatory Toxicology and Pharmacology : RTP·Mark A Pemberton, Ian Kimber
Nov 26, 2021·Expert Review of Respiratory Medicine·Jordan Minov

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