Irritant-induced cyclooxygenase-2 is involved in the defense mechanism of the gastric mucosa in mice

Journal of Gastroenterology
K MiyakeMasafumi Kobayashi

Abstract

Endogenous and exogenous prostaglandins (PGs) have been shown to contribute to reducing the gastric injury caused by irritants given subsequently. The aim of this study was to clarify whether cyclooxygenase-2 (COX-2) protein induced by pretreatment was involved in the prevention of subsequent ethanol-caused gastric injury in mice. Mice were pretreated with acidified ethanol or saline and then COX-2 protein expression in the stomach was immunohistochemically determined every 8h. Mice were administered 95% ethanol 24h after the acidified ethanol pretreatment, and gastric mucosal damage was evaluated macroscopically and histologically. The effects of NS-398 or indomethacin on the 95% ethanol-caused damage were also examined. Acidified ethanol pretreatment induced COX-2 protein expression in lamina propria macrophages of the gastric mucosa, with a peak level 24h after the pretreatment. The 95% ethanol treatment caused gastric mucosal damage. The degree of the damage was not different between mice pretreated with acidified ethanol and those pretreated with saline. However, NS-398 aggravated the ethanol-caused damage only in mice pretreated with acidified ethanol, while indomethacin aggravated the damage, evaluated histologically, ir...Continue Reading

Citations

Sep 27, 2005·Digestive Diseases and Sciences·Katya Gudis, Choitsu Sakamoto
May 17, 2005·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·K MiyakeC Sakamoto
Jul 13, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Shuhei MiuraChoitsu Sakamoto
Jan 29, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ireneusz T Padol, Richard H Hunt
Feb 11, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Shunsuke YamamotoTetsuo Takehara
Sep 6, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Tetsuya TanigawaTetsuo Arakawa

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