PMID: 9555821Apr 29, 1998Paper

Irritation potential of a new topical tretinoin formulation and a commercially-available tretinoin formulation as measured by patch testing in human subjects

Journal of the American Academy of Dermatology
O H Mills, R S Berger

Abstract

A novel tretinoin preparation uses polyolprepolymer-2, a compound designed to reduce skin irritation by helping retain drugs on and in the surface layers of the skin. We used patch testing to measure the effect of polyolprepolymer-2 on tretinoin-associated irritation. Two patch test studies were conducted. The first assessed the effect of polyolprepolymer-2 by comparing commercially-available tretinoin formulations with respective polyolprepolymer-containing formulations of 0.025% tretinoin gel and 0.025%, 0.05%, and 0.1% tretinoin creams. The second assessed the effect of the polyolprepolymer-2 concentration on the potential decrease in irritation by comparing: (1) a commercially-available tretinoin cream with prototype tretinoin creams containing 20% polyolprepolymer-2 at three different concentrations of tretinoin (0.025%, 0.05%, and 0.1%); and (2) the effect of three different polyolprepolymer-2 concentrations (10%, 15%, and 20%) in prototype tretinoin creams on cumulative irritation. Patch agents were assigned to subjects according to a randomization schedule, and during a period of 5 days each subject received three 24-hour exposures to the test materials. Twenty-four hours elapsed between old patch removal and new patch ...Continue Reading

References

Sep 1, 1995·Human & Experimental Toxicology·M YorkL Neilson

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Citations

Feb 15, 2002·Journal of the European Academy of Dermatology and Venereology : JEADV·J E Wolf
Jul 14, 2014·Colloids and Surfaces. B, Biointerfaces·Amit K JainGovind P Agrawal
Feb 6, 2007·Journal of the American Academy of Dermatology·John S StraussUNKNOWN American Academy of Dermatology/American Academy of Dermatology Association
Mar 18, 2010·Internal Medicine Journal·I MarieH Levesque
Apr 29, 1998·Journal of the American Academy of Dermatology·J J Leyden
Apr 29, 1998·Journal of the American Academy of Dermatology·A W LuckyJ W Quigley
Apr 29, 1998·Journal of the American Academy of Dermatology·A W LuckyM E Reddick
Nov 28, 2008·Bioorganic & Medicinal Chemistry Letters·Sungbum KimJahyo Kang
Jan 8, 2000·Dermatologic Clinics·D M Thiboutot
Jun 21, 2007·Journal of Microencapsulation·Gisele A CastroLucas A M Ferreira
May 31, 2008·Bioorganic & Medicinal Chemistry·Hyojung KimHyungil Jung

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