IRS-2 branch of IGF-1 receptor signaling is essential for appropriate timing of myelination

Journal of Neurochemistry
Susanna FreudeMarkus Schubert

Abstract

Insulin-like growth factor (IGF)-1 increases proliferation, inhibits apoptosis and promotes differentiation of oligodendrocytes and their precursor cells, indicating an important function for IGF-1 receptor (IGF-1R) signaling in myelin development. The insulin receptor substrates (IRS), IRS-1 and -2 serve as intracellular IGF-1R adaptor proteins and are expressed in neurons, oligodendrocytes and their precursors. To address the role of IRS-2 in myelination, we analyzed myelination in IRS-2 deficient (IRS-2(-/-)) mice and age-matched controls during postnatal development. Interestingly, expression of the most abundant myelin proteins, myelin basic protein and proteolipid protein was reduced in IRS-2(-/-) brains at postnatal day 10 (P10) as compared to controls. myelin basic protein immunostaining in P10-IRS-2(-/-) mice revealed a reduced immunostaining, but an unchanged regional distribution pattern. In cerebral myelin isolates at P10 unaltered relative expression of different myelin proteins was found, indicating quantitatively reduced but not qualitatively altered myelination. Interestingly, up-regulation of IRS-1 expression and increased IGF-1R signaling were observed in IRS-2(-/-) mice at P10-14, indicating a compensatory me...Continue Reading

References

Mar 1, 1977·The Journal of Cell Biology·G I TennekoonG M McKhann
Apr 1, 1978·Neurochemical Research·J A Benjamins, P Morell
Oct 1, 1973·Journal of Neurochemistry·W T Norton, S E Poduslo
Sep 14, 1995·Nature·X J SunM F White
Aug 15, 1994·Journal of Neuroscience Research·K A Nave
Aug 27, 1993·Annals of the New York Academy of Sciences·F A McMorrisN Marchetti
Feb 1, 1997·European Journal of Morphology·Y Y Dangata, M H Kaufman
Jun 1, 1997·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·L Yenush, M F White
Mar 12, 1998·Nature·D J WithersM F White
Jun 11, 1999·The Journal of Biological Chemistry·S C LiuS R Keller
Jul 15, 1999·Biochemical and Biophysical Research Communications·V R FantinL M Wang
Jan 25, 2000·American Journal of Physiology. Endocrinology and Metabolism·V R FantinS R Keller
Mar 23, 2000·Progress in Neurobiology·B GarbayC Cassagne
Dec 9, 2000·Developmental Neuroscience·S SalvatiM Sanchez
Oct 3, 2002·Neuropeptides·A Joseph D'ErcoleJohn R O'Kusky
Dec 19, 2002·Diabetologia·M BjörnholmJ R Zierath
Dec 6, 2003·Science·Morris F White
Jan 8, 2004·The Journal of Cell Biology·Jenny HsiehFred H Gage
Feb 20, 2007·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·William H LagardeA Joseph D'Ercole
Mar 14, 2007·Journal of Neurochemistry·Qiao-Ling Cui, Guillermina Almazan

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Citations

Apr 6, 2013·Neuroscience Bulletin·Jared T Ahrendsen, Wendy Macklin
Jul 28, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shaday MichánValter D Longo
Sep 11, 2009·International Journal of Environmental Research and Public Health·Suzanne M de la MonteJack R Wands
Oct 15, 2011·Cellular and Molecular Life Sciences : CMLS·Akhlaq A FarooquiVincenza Frisardi
Aug 10, 2011·Brain & Development·Christina SchneiderRegina Trollmann
Feb 3, 2016·Journal of Alzheimer's Disease : JAD·Ming TongSuzanne M de la Monte
Sep 25, 2009·Neurobiology of Aging·George Bartzokis
Oct 16, 2015·Neurobiology of Disease·Martin BerryAnn Logan
Sep 22, 2010·Journal of Neuroscience Research·Jason GalvinHolly Colognato
Sep 17, 2015·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Ming TongSuzanne M de la Monte
Sep 17, 2015·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Ming TongSuzanne M de la Monte
Jun 20, 2012·Frontiers in Neuroendocrinology·John O'Kusky, Ping Ye
Jun 24, 2014·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Yu-Hong JingLi-Ping Gao
Mar 4, 2014·Progress in Neurobiology·Fares BassilWassilios G Meissner
Sep 16, 2016·Journal of Neuroendocrinology·A Kleinridders
Aug 24, 2018·Developmental Neurobiology·Jillian Mei-Ling LiuJosé Javier Otero
Oct 4, 2017·Endocrine Reviews·Antonino BelfioreRiccardo Vigneri

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