Irsogladine maleate suppresses indomethacin-induced elevation of proinflammatory cytokines and gastric injury in rats.

World Journal of Gastroenterology : WJG
Xin ZhangTakashi Kyoi

Abstract

To investigate the mucosal protective effect and the mechanisms of action of the anti-ulcer drug irsogladine maleate in gastric injury induced by indomethacin in rats. Gastric mucosal injury was induced in male Hos:Donryu rats by oral administration of indomethacin at a dose of 48 mg/kg. One hour before indomethacin treatment, animals were orally pretreated with irsogladine maleate at doses of 1 mg/kg, 3 mg/kg or 10 mg/kg. Four hours after indomethacin administration, the animals were sacrificed and their stomachs were rapidly removed and processed for the evaluation of gastric mucosal damage and the determination of the concentrations of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), IL-8 and myeloperoxidase (MPO) in mucosal tissues. Linear hemorrhagic mucosal lesions were observed primarily in the glandular stomach 4 h after oral administration of indomethacin. Pretreatment with irsogladine maleate markedly reduced the number and severity of these lesions in a dose-dependent manner. The mucosal concentrations of proinflammatory cytokines (TNF-alpha, IL-1beta, and IL-8) and MPO, which indicates the degree of mucosal infiltration by neutrophils, increased concomitantly with the occurrence of gastric inju...Continue Reading

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Citations

May 31, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Gehan Moustafa Badr, Jawaher Abdulaziz Al-Mulhim
Jul 2, 2009·Journal of Gastroenterology·Kazuhide HiguchiTetsuo Arakawa
Apr 20, 2010·European Journal of Pharmacology·Amr A FouadWafaey Gomaa
Apr 9, 2010·Basic & Clinical Pharmacology & Toxicology·Ihab T Abdel-Raheem
Apr 20, 2016·Journal of Natural Medicines·Shiyu WangTao Wang
Mar 7, 2014·Fitoterapia·Sílvio Manfredo VieiraThiago Mattar Cunha
Sep 13, 2011·Free Radical Biology & Medicine·Hisato DeguchiKen-ichi Yamada
Dec 28, 2012·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Juho JungUy Dong Sohn
Dec 3, 2009·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Shailja Sood, Arunachalam Muthuraman
Dec 14, 2019·The Journal of Dermatology·Hiromi KatsueTakuro Kanekura
Apr 1, 2020·Advances in Wound Care·Ziqiang ZhangJianjun Du
Feb 10, 2021·Journal of Basic and Clinical Physiology and Pharmacology·Akinleye Stephen Akinrinde, Halimot Olawalarami Hameed
Feb 9, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Porfirio Alonso Ruiz-HurtadoMarco Aurelio Rodriguez-Monroy

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