IRTA1+ monocytoid B cells in reactive lymphadenitis show a unique topographic distribution and immunophenotype and a peculiar usage and mutational pattern of IgVH genes

The Journal of Pathology
S LazziL Leoncini

Abstract

The origin and function of monocytoid B cells (MBCs) are poorly understood. Taking advantage of their strong expression of IRTA1 (a receptor that is also associated with MALT marginal zone B cells), we have comprehensively analysed MBCs in 25 cases of lymphadenitis of different aetiologies, shedding new light on the topographical distribution, immunophenotype and IgV(H) gene usage and mutational profile of this B cell subset. IRTA1(+) MBCs, although predominantly located in the subcapsular and intermediary sinuses, were also observed scattered within germinal centres (GCs) in all lymphadenitis cases examined. The molecular characterization of IgV(H) genes revealed that IRTA1(+) MBCs residing in different areas of the lymph node (subcapsular sinus, intermediary sinuses and GCs) can be clonally related (with intraclonal variation), and that those located in GCs are consistently more mutated and selected for expression of a functional antigen receptor than those located in the sinuses. Moreover, by contrast, IRTA1(+) MBCs in GCs express the memory B cell marker CD27. Finally, in toxoplasmic lymphadenitis, the IRTA1(+) MBC population shows a highly preferential usage of the V(H) genes 3-7 and 3-30 (without any obvious peculiarity i...Continue Reading

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Citations

Jan 5, 2007·Annual Review of Immunology·Randall S Davis
Jan 16, 2010·Human Immunology·Korinna JöhrensIoannis Anagnostopoulos
Apr 1, 2017·Current Opinion in Immunology·Tri Giang Phan, Stuart G Tangye
Jun 22, 2012·Histopathology·Brunangelo FaliniStefano A Pileri
Nov 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Giorgio CattorettiBachir Alobeid
Oct 11, 2008·The American Journal of Pathology·Mario CoccoLorenzo Leoncini

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