IRTAs: a new family of immunoglobulinlike receptors differentially expressed in B cells.

Blood
Ira MillerRiccardo Dalla-Favera

Abstract

The IRTA1 and IRTA2 genes encode immunoglobulinlike cell surface receptors expressed in B cells and involved in chromosome 1q21 translocations in B-cell malignancy. We have now characterized and comparatively analyzed the structure and expression pattern of the entire family of IRTA genes, which includes 5 members contiguously located on chromosome 1q21. The IRTA messenger RNAs are expressed predominantly in the B-cell lineage within discrete B-cell compartments: IRTA1 is specific to the marginal zone, IRTA2 and IRTA3 are found in the germinal center light zone and in intraepithelial and interfollicular regions, and IRTA4 and IRTA5 are expressed predominantly in the mantle zone. All IRTA genes code for transmembrane receptors that are closely related to Fc receptors in their most amino-terminal extracellular domains and that possess cytoplasmic domains containing ITIM (immunotyrosine inhibition motifs)- and, possibly, ITAM (immunotyrosine activation motifs)-like motifs. These structural features suggest that the IRTA receptors may play a role in regulating activation of normal B cells and possibly in the development of neoplasia.

References

Jan 1, 1988·Annual Review of Immunology·A F Williams, A N Barclay
Jun 1, 1995·European Journal of Immunology·M A Campbell, N R Klinman
Nov 4, 1993·Nature·M AzumaC Somoza
Jan 1, 1994·Advances in Immunology·M D Hulett, P M Hogarth
Jun 1, 1993·Current Opinion in Immunology·B Malissen, A M Schmitt-Verhulst
Dec 1, 1995·Immunity·M Van der VierenW M Gallatin
Sep 18, 1997·Immunology Today·S TridandapaniK M Coggeshall
Jan 1, 1997·Annual Review of Cell and Developmental Biology·F S Walsh, P Doherty
Mar 14, 1998·Research in Immunology·J S VerbeekJ G van de Winkel
Jan 12, 1999·The Journal of Clinical Investigation·P J Newman
Jan 16, 1999·The Journal of Biological Chemistry·J BlasioliM L Thomas
Dec 14, 1999·Mammalian Genome : Official Journal of the International Mammalian Genome Society·D FrankB Tycko
Jan 5, 2000·Proceedings of the National Academy of Sciences of the United States of America·M B CallananD Leroux
Apr 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·M J WilsonJ Trowsdale
Aug 10, 2000·Bone Marrow Transplantation·H TeschH Bohlen
Sep 19, 2000·Immunobiology·F HornK Heidrich
Sep 21, 2000·Current Biology : CB·M V Taylor
Feb 13, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·J G SathishR J Matthews
Feb 13, 2001·Biochemical and Biophysical Research Communications·M J XuZ J Zhao
Feb 13, 2001·Leukemia Research·H C MorseE S Jaffe
Apr 21, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·L M ShlapatskaS P Sidorenko
Jun 8, 2001·Proceedings of the National Academy of Sciences of the United States of America·C D JunT A Springer
Aug 9, 2001·Proceedings of the National Academy of Sciences of the United States of America·R S DavisM D Cooper

❮ Previous
Next ❯

Citations

Feb 3, 2007·Immunogenetics·Alexander Iain TaylorRosaleen Ann Calvert
Mar 16, 2007·Immunogenetics·Svetlana A FayngertsAlexander V Taranin
Mar 21, 2013·Rheumatology International·Gwan Gyu SongYoung Ho Lee
Oct 16, 2012·Virchows Archiv : an International Journal of Pathology·Enrico MunariAlberto Zamò
Sep 10, 2003·Seminars in Cancer Biology·Andreas a ViardotMartin Bentz
May 25, 2007·Proceedings of the National Academy of Sciences of the United States of America·Christopher L HagaMax D Cooper
Aug 12, 2005·Current Opinion in Rheumatology·Jennifer A Croker, Robert P Kimberly
Jan 5, 2007·Annual Review of Immunology·Randall S Davis
Mar 9, 2012·Journal of Translational Medicine·Waqar AhmadSajida Hassan
Oct 13, 2004·The Keio Journal of Medicine·Amanda GavinDavid Nemazee
Dec 21, 2002·Immunological Reviews·Randall S DavisMax D Cooper
Apr 9, 2005·Genes and Immunity·T J Wilson, M Colonna
Dec 14, 2007·Autoimmunity·Elizabeth E BrownRobert P Kimberly
Apr 28, 2007·Human Immunology·Dimitry A Chistiakov, Alexander P Chistiakov
Feb 3, 2005·European Journal of Immunology·Randall S DavisMax D Cooper
Oct 20, 2004·British Journal of Haematology·Noraidah MasirDavid Y Mason
Aug 16, 2008·International Journal of Cancer. Journal International Du Cancer·Tohid KazemiFazel Shokri
Sep 18, 2007·British Journal of Haematology·Masako ShimadaKiyoshi Ando
Jun 22, 2012·Histopathology·Brunangelo FaliniStefano A Pileri
Jan 29, 2005·Genomics·N A ChikaevA V Taranin
Oct 6, 2006·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Takeji UmemuraKendo Kiyosawa
Sep 28, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jonathan Maurice ChemounyRenato C Monteiro
Aug 3, 2010·Microbes and Infection·Dina Alzhanova, Klaus Früh
Apr 24, 2016·Biochimica Et Biophysica Acta·Ngoc Phuong Lan LeMax Crispin
May 18, 2016·The International Journal of Biochemistry & Cell Biology·Karsen SetoSubhajit Dasgupta

❮ Previous
Next ❯

Related Concepts

Related Feeds

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
Randall S DavisMax D Cooper
Proceedings of the National Academy of Sciences of the United States of America
Fabio FacchettiM Colonna
© 2022 Meta ULC. All rights reserved