Is 131I ablation necessary for patients with low-risk papillary thyroid carcinoma and slightly elevated stimulated thyroglobulin after thyroidectomy?

Archives of Endocrinology and Metabolism
Pedro Weslley Rosário, Gabriela F Mourão

Abstract

This prospective study evaluated the recurrence rate in low-risk patients with papillary thyroid cancer (PTC) who presented slightly elevated thyroglobulin (Tg) after thyroidectomy and who did not undergo ablation with131I. The study included 53 low-risk patients (nonaggressive histology; pT1b-3, cN0pNx, M0) with slightly elevated Tg after thyroidectomy (> 1 ng/mL, but ≤ 5 ng/mL after levothyroxine withdrawal or ≤ 2 ng/mL after recombinant human TSH). The time of follow-up ranged from 36 to 96 months. Lymph node metastases were detected in only one patient (1.9%). Fifty-two patients continued to present negative neck ultrasound. None of these patients without apparent disease presented an increase in Tg. Low-risk patients with PTC who present slightly elevated Tg after thyroidectomy do not require ablation with 131I.

References

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Aug 5, 2004·The Journal of Clinical Endocrinology and Metabolism·Gabriella PellegritiAntonino Belfiore
Feb 4, 2005·The Laryngoscope·Pedro Weslley Souza de RosárioAlvaro Luis Barroso
Sep 24, 2005·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Pedro Weslley Souza RosárioAlvaro Luís Barroso
Nov 16, 2007·Thyroid : Official Journal of the American Thyroid Association·Pedro W S RosárioSaulo Purisch
Oct 29, 2009·Thyroid : Official Journal of the American Thyroid Association·UNKNOWN American Thyroid Association (ATA) Guidelines Taskforce on Thyroid Nodules and Differentiated Thyroid CancerR Michael Tuttle
Oct 20, 2010·Thyroid : Official Journal of the American Thyroid Association·Pedro Weslley RosarioMaria Regina Calsolari
Oct 12, 2012·Thyroid : Official Journal of the American Thyroid Association·Pedro Weslley RosarioMaria Regina Calsolari
Jan 8, 2013·The Journal of Clinical Endocrinology and Metabolism·Cosimo DuranteUNKNOWN PTC Study Group
Jul 6, 2013·Arquivos brasileiros de endocrinologia e metabologia·Pedro Weslley RosárioUNKNOWN Sociedade Brasileira de Endocrinologia e Metabologia
Nov 20, 2013·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Pedro W RosárioMaria Regina Calsolari

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Citations

Feb 26, 2016·Archives of Endocrinology and Metabolism·Rosalia do Prado Padovani
Dec 16, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Ying HeLing-Ge Wei

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