Is 5-HTTLPR linked to the response of selective serotonin reuptake inhibitors in MDD?

European Archives of Psychiatry and Clinical Neuroscience
Ari IlliTerho Lehtimäki

Abstract

The role of a functional polymorphism in the transcriptional control region of serotonin transporter gene (5-HTTLPR, SERTPR) has been studied intensively in major depression and in the response to selective serotonin inhibitors (SSRIs) in major depression. The findings have been contradictory, although majority of the studies indicate that the short allele is associated with poor response to SSRIs in major depression. In the present study, we evaluated the association of 5-HTTLPR with treatment response to SSRI medication in Finnish Caucasian MDD patients. A secondary purpose was to study the possible association of this particular polymorphism with major depressive disorder. The aim of the study was to replicate the previous findings in this area. Primary outcomes of the treatment were remission, defined by an exit score of seven or less, and response, defined by a reduction of at least 50% on the MADRS. We had also a control population of 375 healthy blood donors, as a secondary objective was to evaluate the possible association of this particular polymorphism with major depressive disorder. Twenty-nine of the 85 (34.1%) patients reached the remission and 58.8% achieved the predefined response criteria. The l/l genotype of 5-...Continue Reading

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Citations

Feb 18, 2011·European Archives of Psychiatry and Clinical Neuroscience·P Falkai, H-J Möller
Apr 3, 2012·Acta Physiologica·E KirillyG Bagdy
Oct 25, 2013·International Review of Psychiatry·C Anthony AltarDavid Mrazek
Jun 17, 2014·Expert Opinion on Drug Metabolism & Toxicology·Chiara FabbriAlessandro Serretti
Sep 5, 2012·Pharmacology & Therapeutics·Yvet KroezeJudith R Homberg
Mar 6, 2015·Nordic Journal of Psychiatry·Kadri AndreEsa Leinonen
Dec 26, 2012·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Andrew A CrawfordMarcus R Munafò
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Nov 28, 2016·Drug Metabolism and Personalized Therapy·Marta RamosMª Pilar Ribate
Jun 3, 2014·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Chiara FabbriAlessandro Serretti

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