Is 99m Tc bone scintigraphy necessary in the preoperative workup for patients with cT1N0 subsolid lung cancer? A prospective multicenter cohort study.

Thoracic Cancer
Hang LiHaiquan Chen

Abstract

99m Tc bone scintigraphy (BS) is still the most common approach for the evaluation of bone metastasis in China. The purpose of this study was to investigate the necessity of BS as part of a routine preoperative workup for patients with cT1N0 subsolid lung cancer. This was a prospective multicenter clinical trial (NCT03689439). Patients with cT1N0 subsolid nodules who were candidates for surgical resection were consecutively enrolled into the study. BS was performed preoperatively. The surgical plan could be changed if a positive result was detected. The primary endpoint was the incidence rate of the surgical plan being changed because of positive BS results. The secondary endpoint was the rate of positive BS findings and the rate of related complications. From November 2018 to July 2019, 691 patients were enrolled into the study. None of the patients had positive BS results and no surgical plans were changed by BS findings. There were 222 male and 469 female patients. The average age was 54.8 ± 3.7 years old. The average tumor diameter was 14.9 ± 4.2 mm. There were 282 patients with pure GGO nodules and 409 with part-solid nodules. A total of 470 patients had a single nodule, while 221 patients had multifocal lesions. The numbe...Continue Reading

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References

Dec 15, 2006·The New England Journal of Medicine·Alan SandlerDavid H Johnson
Aug 6, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·UNKNOWN NSCLC Meta-Analyses Collaborative Group
Mar 5, 2010·CA: a Cancer Journal for Clinicians·Andrew M D WolfUNKNOWN American Cancer Society Prostate Cancer Advisory Committee
Jan 7, 2011·Revista española de medicina nuclear·H Portilla-QuattrociocchiJ M Carril
Jan 22, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·William D TravisDavid Yankelewitz
Jan 29, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Chantal DecroisetteUNKNOWN Groupe Français de Pneumo-Cancérologie 0601 Team
May 31, 2015·Clinics in Chest Medicine·Patricia M de GrootJeremy J Erasmus
Aug 21, 2015·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·William D TravisUNKNOWN WHO Panel
Jun 6, 2016·European Journal of Nuclear Medicine and Molecular Imaging·T Van den WyngaertUNKNOWN EANM Bone & Joint Committee and the Oncology Committee.
May 4, 2017·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Kari ChanskyUNKNOWN IASLC Staging and Prognostic Factors Committee, Advisory Boards, and Participating Institutions

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Clinical Trials Mentioned

NCT03689439

Software Mentioned

PASS
SPSS

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