Is a dietary n-3 fatty acid supplement able to influence the cardiac effect of the psychological stress?

Molecular and Cellular Biochemistry
Delphine RousseauA Grynberg

Abstract

Epidemiological studies suggest that n-3 polyunsaturated fatty acids (PUFA) are involved in the prevention of cardiovascular disease. Stress is known to increase the incidence of CVD and the present study was realised to evaluate some physiological and biochemical effects of dietary docosahexaenoic acid (DHA) in male Wistar rats subjected to a psycho social stress. Rats were fed for 8 weeks a semi-purified diet containing 10% of either sunflower seed oil or the same oil supplemented with DHA. This food supply represented 50% of their daily requirement. The remaining 50% were supplied as 45 mg food pellets designed to induce stress in rats by an intermittent-feeding schedule process. The control group (n = 12) was fed the equivalent food ration as a single daily feeding. The physiological cardiovascular parameters were recorded by telemetry through a transmitter introduced in the abdomen. At the end of the experimentation, the heart and adrenals were withdrawn and the fatty acid composition and the catecholamine store were determined. Dietary DHA induced a pronounced alteration of the fatty acid profile of cardiac phospholipids (PL). The level of all the n-6 PUFAs was reduced while 22:6 n-3 was increased. The stress induced a si...Continue Reading

Citations

Jan 11, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Delphine RousseauAlain Grynberg
Jul 23, 1999·Annals of the New York Academy of Sciences·H Rupp
Dec 22, 1999·The American Journal of Physiology·J M MaixentM Bernard
Nov 23, 2005·Journal of Human Hypertension·P Valensi
May 29, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Adey Ayalew-PervanchonAlain Grynberg
Jun 1, 2005·Nutrition Research Reviews·Mark HamerJoris Kloek
Mar 25, 2008·Progress in Lipid Research·Tomohito Hamazaki, Kei Hamazaki
Jul 11, 2006·Journal of Proteome Research·Yulan WangJeremy K Nicholson

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