Is a gene-centric human proteome project the best way for proteomics to serve biology?

Proteomics
Thierry RabilloudR J Simpson

Abstract

With the recent developments in proteomic technologies, a complete human proteome project (HPP) appears feasible for the first time. However, there is still debate as to how it should be designed and what it should encompass. In "proteomics speak", the debate revolves around the central question as to whether a gene-centric or a protein-centric proteomics approach is the most appropriate way forward. In this paper, we try to shed light on what these definitions mean, how large-scale proteomics such as a HPP can insert into the larger omics chorus, and what we can reasonably expect from a HPP in the way it has been proposed so far.

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Citations

Sep 15, 2012·Journal of the American Society for Mass Spectrometry·Neil L Kelleher
Sep 13, 2012·Omics : a Journal of Integrative Biology·Elena PonomarenkoAlexander Archakov
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Oct 18, 2020·Nature Communications·Subash AdhikariMark S Baker

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