PMID: 8600476Nov 1, 1995Paper

Is a history of depressive symptoms associated with an increased risk of infertility in women?

Psychosomatic Medicine
K L LapaneA L Hume

Abstract

Researchers have reported an association between self-reported antidepressant use and increased risk of ovulatory infertility but could not control for confounding by the drug indication. We evaluated the role of depressive symptoms in the development of infertility. We recontacted a population-based sample of Pawtucket Heart Health Program (PHHP) health survey respondents to perform this case-control study. Self-reported infertility was defined as an inability to conceive after 12 months of unprotected intercourse. Controls were women who reported at least one pregnancy. The index age for infertile women was the age at which they first experienced fertility problems, and for the fertile women it was the age of their first pregnancy. History of depressive symptoms was based on self-report before the index age. Women with a history of depressive symptoms were nearly twice as likely to report infertility relative to women without a history of depressive symptoms before the index age after controlling for potential confounders (90% confidence interval: 0.9-3.2). Our data suggest that depressive symptoms as well as the drugs used to treat these conditions may play an important role in the pathogenesis of infertility. The associatio...Continue Reading

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Citations

Feb 11, 2014·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Julie MerrellLeslie Heinberg
Mar 6, 2012·Journal of Immigrant and Minority Health·Penina Segall-GutierrezJanet Pine
Oct 12, 2012·Der Nervenarzt·U SchweigerT Strowitzki
Feb 13, 2001·Psychoneuroendocrinology·W H MellerG E Tagatz
Jul 8, 2008·Taiwanese Journal of Obstetrics & Gynecology·Laya Farzadi, Aliyeh Ghasemzadeh
Apr 14, 2010·The Psychiatric Clinics of North America·Kirsten M WilkinsElka Serrano
Oct 17, 2007·The Psychiatric Clinics of North America·Linda Hammer Burns
Nov 16, 2004·European Journal of Obstetrics, Gynecology, and Reproductive Biology·J CwikelE Sheiner
Jun 17, 1998·Fertility and Sterility·K DemyttenaereT D'Hooghe
May 2, 2016·American Journal of Obstetrics and Gynecology·Yael I NillniLauren A Wise
Nov 9, 2004·BMC Women's Health·Fatemeh RamezanzadehMina Jafarabadi
Dec 13, 2005·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Robert P KauffmanRon Owens
Apr 25, 2007·Pharmacoepidemiology and Drug Safety·Carlos De Las CuevasE J Sanz
Aug 20, 2008·Journal of Women's Health·Nicole W KarjaneDace S Svikis
Feb 21, 2019·Journal of Psychosomatic Obstetrics and Gynaecology·Esra Nur TolaBaha Oral
Feb 12, 2017·Journal of Women's Health·Sara CrawfordViolanda Grigorescu
Sep 27, 2007·Human Reproduction Update·Katherine E WilliamsNatalie L Rasgon
Jul 19, 2003·Human Fertility : Journal of the British Fertility Society·Jim Monach

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