Is ACE gene polymorphism a useful marker for diabetic albuminuria in Japanese NIDDM patients?

Diabetes Care
S NakajimaY Yajima

Abstract

We studied the relationship between an insertion/deletion (I/D) polymorphism in the ACE gene and albuminuria/proteinuria in Japanese NIDDM patients. A total of 142 Japanese NIDDM patients (89 men, 53 women) with a known diabetes duration of 14 +/- 5 (mean +/- SD) years and an age of 56 +/- 6 years were divided into three groups according to the stage of nephropathy: 41 patients with normoalbuminuria, 47 patients with microalbuminuria, and 54 with overt proteinuria. The three groups were similar in age, diabetes duration, and recent HbAic level. The distribution of DD, ID, and II genotypes of the ACE gene did not differ among the three groups (10, 46, and 44% in the normoalbuminuric patients; 13, 53, and 34% in the microalbuminuric patients; and 15, 46, and 39% in the proteinuric patients, respectively). Meanwhile, the frequency of the D allele in the proteinuric male patients was slightly higher than in the normoalbuminuric male patients (45 vs. 27%, chi 2 = 3.9, P < 0.05), while the D allele frequency was nonsignificantly lower in the proteinuric female patients than in the normoalbuminuric female patients. These results did not support the hypothesis that the genotype of the ACE gene would be a clinically useful genetic marke...Continue Reading

Citations

Oct 20, 2001·Diabetes Research and Clinical Practice·M ArazA Sükrü Aynacioglu
May 2, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Sung-Kyu HaDae Suk Han
Jul 3, 1999·Diabetic Medicine : a Journal of the British Diabetic Association·B KennonJ M Connell
May 10, 2007·The Review of Diabetic Studies : RDS·Rachel M FreathyKenneth M Macleod
Nov 24, 2007·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·B Kennon, J M Connell

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biomarkers for Diabetes

This feed focuses on the latest research on biomarkers used for monitoring disease progression in diabetes.

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.

American Diabetes Association Journals

Discover the latest diabetes research published by the journals from the American Diabetes Association.