Is Akt the "Warburg kinase"?-Akt-energy metabolism interactions and oncogenesis.

Seminars in Cancer Biology
R Brooks Robey, Nissim Hay

Abstract

The serine/threonine kinase Akt - also known as protein kinase B (PKB) - has emerged as one of the most frequently activated protein kinases in human cancer. In fact, most, if not all, tumors ultimately find a way to activate this important kinase. As such, Akt activation constitutes a hallmark of most cancer cells, and such ubiquity presumably connotes important roles in tumor genesis and/or progression. Likewise, the hypermetabolic nature of cancer cells and their increased reliance on "aerobic glycolysis", as originally described by Otto Warburg and colleagues, are considered metabolic hallmarks of cancer cells. In this review, we address the specific contributions of Akt activation to the signature metabolic features of cancer cells, including the so-called "Warburg effect".

References

Jul 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·S P StaalW P Rowe
May 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·P F JonesB A Hemmings
Jul 1, 1984·Archives of Biochemistry and Biophysics·E Aubert-FoucherD C Gautheron
Jan 1, 1995·Reviews of Physiology, Biochemistry and Pharmacology·J E Wilson
Mar 15, 1997·Genes & Development·S G KennedyN Hay
Aug 4, 2001·Molecular and Cellular Biology·M G Vander HeidenC B Thompson
Dec 26, 2001·The Journal of Biological Chemistry·John G PastorinoJan B Hoek
Feb 8, 2002·The Journal of Biological Chemistry·Yin GuoEmad S Alnemri
Jun 18, 2002·The Journal of Biological Chemistry·John D RobertsonSten Orrenius
Jul 11, 2002·The Journal of Biological Chemistry·Daniel C BerwickJeremy M Tavare
Sep 5, 2002·Nature Reviews. Cancer·William G Kaelin
Sep 6, 2003·Cancer Cell·James B BrugarolasWilliam G Kaelin
Jun 3, 2004·The Journal of Biological Chemistry·Klaus W WagnerQuinn L Deveraux
Jun 24, 2004·Seminars in Cell & Developmental Biology·Ramon Parsons
Aug 18, 2004·Genes & Development·Nissim Hay, Nahum Sonenberg
Apr 23, 2005·Cell Cycle·R Brooks Robey, Nissim Hay
May 4, 2005·Biochemical and Biophysical Research Communications·Boris Zhivotovsky, Sten Orrenius
Jul 12, 2005·Oncogene·Daniel E BauerCraig B Thompson
Jul 20, 2005·The Journal of Biological Chemistry·Annett Hahn-WindgassenNissim Hay
Sep 21, 2005·The Journal of Biological Chemistry·Zhonghua GaoXuejun Jiang
Dec 6, 2005·Nature Reviews. Cancer·Eyal Gottlieb, Ian P M Tomlinson
Jul 19, 2006·Nature Reviews. Genetics·Jeffrey A EngelmanLewis C Cantley
Aug 8, 2006·Oncogene·M BrandonD C Wallace
Sep 20, 2006·Cancer Research·Jung-whan Kim, Chi V Dang
Oct 24, 2006·Nature Reviews. Molecular Cell Biology·Nicholas K Tonks

❮ Previous
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Citations

Jan 9, 2013·Annual Review of Pharmacology and Toxicology·Naval P ShanwareRobert T Abraham
Jul 20, 2014·Cellular and Molecular Life Sciences : CMLS·Do-Yeon KimJihye Paik
Oct 22, 2009·PloS One·Valeria Gabriela Antico ArciuchJuan José Poderoso
Nov 3, 2010·Proceedings of the National Academy of Sciences of the United States of America·Ayaz Najafov, Dario R Alessi
Dec 3, 2010·The Journal of Clinical Investigation·Hamid Reza RezvaniDavid R Bickers
Jan 5, 2011·Frontiers in Bioscience (Landmark Edition)·Yuhua ZhaoMing Tan
Feb 16, 2011·Proceedings of the National Academy of Sciences of the United States of America·Olivier KeunenSimone P Niclou
Feb 18, 2011·Cancer Research·Jimmy K StaufferRobert H Wiltrout
Aug 2, 2011·Canadian Urological Association Journal = Journal De L'Association Des Urologues Du Canada·Jehonathan H PinthusNathan Rothschild
Sep 9, 2011·The Journal of Biological Chemistry·Elizabeth A StollPhilip J Horner
Oct 5, 2011·Antioxidants & Redox Signaling·Valeria Gabriela Antico ArciuchMaría Cecilia Carreras
Jan 11, 2013·American Journal of Physiology. Cell Physiology·Shu-jen ChenBarbara A Miller
Oct 5, 2013·Experimental & Molecular Medicine·Miran JangJinhwa Lee
Jan 10, 2013·Science Signaling·Kui Lin
Sep 21, 2011·Der Pathologe·D F Calvisi
Mar 31, 2011·Archivum Immunologiae Et Therapiae Experimentalis·Paweł Piątkiewicz, Anna Czech
Oct 28, 2011·Nutrition & Metabolism·Rainer J Klement, Ulrike Kämmerer
Jul 16, 2013·Clinical Oncology : a Journal of the Royal College of Radiologists·J S Good, K J Harrington
Apr 30, 2010·Molecular Neurobiology·Alison Colquhoun
Feb 19, 2013·The International Journal of Biochemistry & Cell Biology·Xu-Hui LiHai-Meng Zhou
Oct 8, 2013·Oncogene·T Hitosugi, J Chen
Jan 20, 2016·European Journal of Clinical Investigation·Ana F BrancoTeresa Cunha-Oliveira
Jun 5, 2014·International Journal of Cancer. Journal International Du Cancer·James L Thorne, Moray J Campbell
Apr 9, 2013·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Jun-gang ZhangChun-you Wang
Mar 10, 2015·Pharmacology & Therapeutics·Noel A Warfel, Andrew S Kraft
Jan 12, 2013·European Journal of Cell Biology·Remco van HorssenFrancesca Attanasio
Nov 20, 2012·Pharmacology & Therapeutics·Mohita UpadhyayPerumal Vivekanandan

❮ Previous
Next ❯

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