Apr 7, 2007

Is all ventricular fibrillation the same? A comparison of ischemically induced with electrically induced ventricular fibrillation in a porcine cardiac arrest and resuscitation model

Critical Care Medicine
James T NiemannRoger J Lewis


The standard porcine cardiac arrest model uses electrical induction of ventricular fibrillation. Reported restoration of spontaneous circulation and survival rates in this model are as high as 90% for ventricular fibrillation durations of 7-10 mins, values substantially greater than rates in the clinical population (i.e., 20% to 30%). A high first shock success rate, infrequent refibrillation, and short times for restoration of spontaneous circulation are typical of the model. The purpose of this study was to determine whether ischemic induction of ventricular fibrillation in swine followed by standard advanced cardiac life support would result in short-term outcomes approximating those observed in human victims of out-of-hospital ventricular fibrillation. Randomized comparative trial. Translational research laboratory. Domestic swine (n = 40, mean weight 40 +/- 4 kg, range 34-47 kg) of both genders. Swine were instrumented and randomized to either electrical ventricular fibrillation induction or ischemic ventricular fibrillation, produced by balloon occlusion of the mid-left anterior descending coronary artery (n = 20 per group). Transthoracic impedance was measured and 30 Omega added in series for all animals. The balloon rem...Continue Reading

Mentioned in this Paper

Ventricular Fibrillation
Anti-Arrhythmia Agents
Basic Cardiac Life Support
Sleep Disorders, Circadian Rhythm
Cardiac Depressants
Epinephrine Measurement
Sinus Node Artery

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