Is allergy screening of blood donors necessary? A comparison between questionnaire answers and the presence of circulating IgE antibodies

Vox Sanguinis
A SternS G Johansson

Abstract

We investigated 477 consecutive blood donors on order to find the predictive value of a questionnaire as a screening method for preventing passive transfer of IgE antibodies to common allergens that might cause transfusion reactions. Of the 477 donors, 119 (24.9%) claimed to be allergic and 358 (75.1%) recorded no allergic complaints. Serological examination with Phadiatop and a multi-allergen mix for food (fx5) detected IgE antibodies in only 54.5% of the allegedly allergic blood donors. Among the allegedly asymptomatic donors, 12.3% showed positive results in these tests. Subsequently, radioallergosorbent test analyses with common inhalant and food allergens were performed to specify the IgE responses obtained. Our results demonstrate a remarkable difference between the questionnaire answers and the serological measurements of IgE antibodies and raise the question of whether - and if so, what kind of - allergy screening is warranted among presumptive blood donors.

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Citations

Apr 29, 2010·Current Allergy and Asthma Reports·Dan Atkins, Jonathan Malka-Rais
Jun 1, 2005·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·I TaziN Benchemsi
Aug 4, 2005·Allergy·S G O JohanssonH Oman
Sep 25, 2012·Transfusion·William J SavagePaul M Ness
Jan 11, 2014·Transfusion·Jessica L PoissonJames P AuBuchon
Sep 3, 2014·Transfusion Medicine·A PonnampalamM Bigham
May 10, 2015·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·O GarraudF Cognasse
Jun 21, 2001·Blood Reviews·P L Perrotta, E L Snyder

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