Is AMP-Activated Protein Kinase Associated to the Metabolic Changes in Primary Ovarian Insufficiency?

Antioxidants & Redox Signaling
José M Navarro-PandoElísabet Alcocer-Gómez

Abstract

Primary ovarian insufficiency (POI) is a critical fertility defect characterized by anticipated impairment of the follicular reserve, which pathophysiological mechanisms have not yet been identified. We have investigated the possible relationship between AMP-activated protein kinase (AMPK) and the pathophysiology of POI. We studied 35 POI patients with altered levels of follicle-stimulating hormone (FSH) and estradiol and increased percentage of overweight compared with 20 healthy women. Blood mononuclear cells from POI patients showed reduced levels of phosphorylated AMPK, adenosine triphosphate, and high serum levels of leptin and tumor necrosis factor-alpha. All these alterations were also observed in granulosa cells, a more closer environment of the ovary. Significant negative correlations between AMPK and body mass index, FSH and leptin levels, and a positive correlation between AMPK and estradiol levels were observed. Oral metformin supplementation restored biochemical parameters. Interestingly, AMPK levels from patients were negatively correlated with age, suggesting an accelerated aging in POI mediated by the impairment of AMPK. These results lead to the hypothesis that an impairment of AMPK could be implicated in the m...Continue Reading

References

Sep 27, 2014·Current Opinion in Cell Biology·D Grahame Hardie
May 18, 2016·Obstetrical & Gynecological Survey·Vikram Sinai TalaulikarEphia Yasmin
Jun 15, 2016·The Journal of Clinical Endocrinology and Metabolism·Nadine M P DaanBart C J M Fauser
Nov 19, 2017·Trends in Endocrinology and Metabolism : TEM·Mario D CorderoBernhard Ryffel
Jul 2, 2011·Reproductive Medicine and Biology·Toshifumi TakahashiHirohisa Kurachi
May 1, 2018·Trends in Endocrinology and Metabolism : TEM·Ilpo HuhtaniemiMicheline Misrahi

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