PMID: 9649959Jul 3, 1998Paper

Is antihypertensive treatment the same for NIDDM and IDDM patients?

Diabetes Research and Clinical Practice
H H Parving

Abstract

The prevalence of abnormally elevated albumin excretion rate (> 30 mg/24 h) is approximately 40% in insulin-dependent (IDDM) and non-insulin-dependent (NIDDM) diabetic patients. Diabetes has become the leading cause of end-stage renal failure in the US, Japan and Europe. Approximately 90% of the direct and indirect cost of caring for diabetic patients are spent on the complications of diabetes. Identification of patients at high risk of developing diabetic nephropathy is possible by screening for microalbuminuria (30-300 mg/24 h). Elevated urinary albumin excretion rate indicates a substantially increased mortality risk in diabetic patients. Randomised controlled trials in normotensive IDDM and NIDDM patients with persistent microalbuminuria indicate that ACE inhibitors diminish urinary albumin excretion rate, postpone it and may even prevent progression to clinical overt nephropathy. These findings indicate that screening and intervention programs are likely to have life saving effects and lead to considerable economic savings. Systemic blood pressure elevation to a hypertensive level is an early and frequent phenomenon in diabetic nephropathy. Furthermore, nocturnal blood pressure elevation (non-dippers) occurs more frequentl...Continue Reading

References

Feb 1, 1989·Archives of Internal Medicine·R KleinD L DeMets
Oct 1, 1993·Diabetes Care
Oct 1, 1996·Archives of Family Medicine·G C Groggel

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Citations

Mar 3, 2007·Pharmacy World & Science : PWS·Ahmet AkiciSule Oktay
Mar 21, 2002·Diabetes, Obesity & Metabolism·R Estacio
Aug 19, 1999·Cell Biochemistry and Function·B UstündagN Ilhan

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