Is arterial calcification in children and adolescents with end-stage renal disease a rare finding?

Nephrology
Fernanda L de MenezesHeitor P Leite

Abstract

To investigate if calcification and intimal media thickness (IMT) of arteries are present in children and adolescents with end-stage renal disease and to describe the risk factors associated with these alterations. In an observational, cross-sectional prospective study, 68 patients were evaluated at the time of renal transplantation. A fragment of the inferior epigastric artery was removed during surgery for histopathological analysis to verify the presence or not of arterial calcification. Two outcomes were considered: the presence of calcium deposition and the measurement of the IMT of the artery. The potential exposure variables were: age, chronic kidney disease aetiology, diagnosis time, systolic blood pressure (SBP), use of oral active vitamin D, homocysteine and C-reactive protein. No arterial calcification was observed in the studied sample. The median value of the IMT of the inferior epigastric artery was 166 μm (interquartile range = 130-208). SBP standard deviation score and age were the only factors associated with this outcome. There was no statistical interaction between SBP and age with the IMT (P = 0.280). Arterial calcification is rare in children and adolescents with end-stage renal disease. The factors associa...Continue Reading

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Citations

Nov 13, 2020·Arteriosclerosis, Thrombosis, and Vascular Biology·Frank RutschYvonne Nitschke

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