Is baseline autonomic tone associated with new onset atrial fibrillation?: Insights from the framingham heart study

Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc
Jagmeet P SinghEmelia J Benjamin

Abstract

Recent reports have indicated that autonomic tone fluctuations measured by heart rate variability (HRV) precede episodes of paroxysmal atrial fibrillation (AF). Little is known about the impact of baseline autonomic tone and the development of new onset AF in a population-based cohort. The purpose of this study was to assess the role of HRV as a predictor of new onset AF. Ambulatory ECG recordings obtained from the Framingham Heart Study subjects attending a routine examination were processed for HRV. The HRV variables analyzed included standard deviation of normal R-R intervals (SDNN), low frequency power (LF), high frequency power (HF), and LF/HF ratio. There were 1434 women and 1142 men (54 +/- 14.1 years) eligible for the study. In 12 years of follow-up, 65 women and 67 men had new onset AF. The study had 80% power to detect a hazard ratio (HR) of 1.3 per standard deviation (SD) decrement in HRV. A one SD decrement in log LF/HF was associated with increased risk of developing AF (HR = 1.23; 95% confidence intervals (CI) = 1.06-1.44) in age- and sex-adjusted models; the association was no longer significant (HR = 1.15; 95% CI = 0.98-1.35) after adjusting for potential confounders. Autonomic dysregulation at baseline, as refl...Continue Reading

References

Sep 1, 1979·American Journal of Epidemiology·W B KannelW P Castelli
Sep 1, 1974·Cardiovascular Research·D P ZipesG T Robbins
Oct 1, 1993·The American Journal of Cardiology·M Malik, A J Camm
Aug 1, 1996·Cardiovascular Research·F LombardiS Cerutti
Oct 1, 1996·Journal of Cardiovascular Electrophysiology·P Coumel
Nov 15, 1996·Journal of the American College of Cardiology·H TsujiD Levy
Jun 3, 1999·Pacing and Clinical Electrophysiology : PACE·M FioranelliA Puglisi
Dec 22, 1999·Pacing and Clinical Electrophysiology : PACE·Y BlaauwH J Crijns
Jun 12, 2002·Circulation·Marco Bettoni, Marc Zimmermann
May 22, 1963·Annals of the New York Academy of Sciences·T R DAWBERL P LYELL
Mar 1, 1951·American Journal of Public Health and the Nation's Health·T R DAWBERF E MOORE

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Citations

Feb 2, 2013·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Stefanie HillebrandOlaf M Dekkers
Jun 5, 2010·Indian Journal of Pharmacology·J Singh, J S Braich
Oct 13, 2009·European Journal of Internal Medicine·Sunil T MathewSatheesh Joseph
Oct 28, 2008·Pacing and Clinical Electrophysiology : PACE·Mirela OvreiuC Allen Bashour
Oct 1, 2005·Progress in Cardiovascular Diseases·Brian Olshansky
Oct 18, 2019·Journal of Research in Medical Sciences : the Official Journal of Isfahan University of Medical Sciences·Akiko NodaYoshinari Yasuda
Jun 1, 2016·JACC. Clinical Electrophysiology·Lior BibasJonathan Afilalo

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