Is betahistine effective for Ménière’s disease?

Medwave
Andrés Rosenbaum, Matías Winter

Abstract

Meniere’s disease is an inner ear disorder characterized by episodes of spontaneous vertigo, fluctuating hearing loss and tinnitus. Betahistine has been used to reduce intensity and frecuency of vertigo attacks, but there is controversy regarding its effectiveness. To answer this question we used Epistemonikos, the largest database of systematic reviews in health, which is maintained by screening multiple information sources, including MEDLINE, EMBASE, Cochrane, among others. We extracted data from the systematic reviews, reanalyzed data of primary studies, conducted a meta-analysis and generated a summary of findings table using the GRADE approach. We identified four systematic reviews including 12 trials overall. We concluded betahistine might reduce the number of attacks, vertigo intensity and lead to a symptomatic improvement according to global judgement in patients with Meniere’s disease, but the certainty of evidence is low. On the other hand, it probably does not have significant adverse effects.

References

Sep 1, 1995·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
May 2, 2001·The Cochrane Database of Systematic Reviews·A L James, M J Burton
Feb 13, 2003·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Eugenio MiraP Frasconi
Jun 20, 2013·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Jozef J P Nauta
Jan 27, 2016·Brazilian Journal of Otorhinolaryngology·Seyed Javad Seyed TootoonchiDaniel Fadaei Fouladi
Jun 22, 2016·The Cochrane Database of Systematic Reviews·Louisa MurdinAnne G M Schilder

❮ Previous
Next ❯

Citations

Jan 16, 2019·Journal of Molecular Neuroscience : MN·Shuxia QianXiaoling Zhang
Jun 17, 2020·Expert Opinion on Pharmacotherapy·Juan Manuel Espinosa-Sanchez, José A Lopez-Escamez

❮ Previous
Next ❯

Related Concepts

Related Feeds

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.