Is birth weight modified during pregnancy? Using sibling differences to understand the impact of blood glucose, obesity, and maternal weight gain in gestational diabetes

American Journal of Obstetrics and Gynecology
Jennifer A HutcheonGrace M Egeland

Abstract

The purpose of this study was to examine the extent to which blood glucose, obesity, and maternal weight gain explains differences in birth weight using offspring sibling pairs in gestational diabetes mellitus (GDM). A retrospective analysis of 90 women with at least 2 GDM pregnancies was conducted. A fixed effects model was used to examine differences between siblings of the same mother (within-women), and results were contrasted with a multivariable regression model that compared different mothers (between-women). Higher maternal weight gain was significantly associated with increased birth weight within mothers, but not between different women. Conversely, overweight status (body mass index [BMI] > or = 25) was significant between-mothers, but not within an individual mother's pregnancies. One-hour postprandial glucose was significant between-mothers, with a weaker association within-mothers. There was no association between fasting glucose and birth weight in either analysis. Controlling pregnancy weight gain may reduce offspring birth weight in individual women with GDM, while the association between high birth weight and elevated prepregnancy BMI may represent a predisposition to both characteristics.

References

Apr 1, 1994·American Journal of Obstetrics and Gynecology·O LangerF Arrendondo
Aug 1, 1993·The Australian & New Zealand Journal of Obstetrics & Gynaecology·T CundyA Roberts
Jan 1, 1997·Genetic Epidemiology·T H BeatyK Y Liang
Sep 1, 2000·BMJ : British Medical Journal·G M EgelandL M Irgens
Aug 3, 2001·Pediatrics·M S KramerUNKNOWN Fetal/Infant Health Study Group of the Canadian Perinatal Surveillance System
Mar 4, 2003·Pediatrics·Matthew W GillmanGraham A Colditz
Apr 23, 2005·American Journal of Obstetrics and Gynecology·Oded LangerElly M J Xenakis

❮ Previous
Next ❯

Citations

Dec 30, 2014·BioMed Research International·Laura GaudetMark Walker
Jun 9, 2009·Obstetrics and Gynecology Clinics of North America·Yariv Yogev, Patrick M Catalano
Jun 9, 2009·Obstetrics and Gynecology Clinics of North America·Emily Oken
Apr 9, 2008·European Journal of Pharmacology·Gertjan van Dijk, Bauke Buwalda
Mar 29, 2011·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Z B YuX R Guo
Jul 31, 2013·Pediatric Diabetes·Charlotta NilssonMona Landin-Olsson
Feb 24, 2016·American Journal of Obstetrics and Gynecology·L C HoughtonM B Terry
Dec 22, 2011·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Orli Most, Oded Langer
Oct 1, 2014·Best Practice & Research. Clinical Obstetrics & Gynaecology·D MitanchezU Simeoni
Feb 16, 2017·American Journal of Epidemiology·Wietske A EsterMary Beth Terry
Jan 24, 2015·The British Journal of Nutrition·Ragia H GhoneimMicheline Piquette-Miller
May 3, 2014·Journal of Family Medicine and Primary Care·Abeer Al Shahrani, Muneera Baraja
Nov 17, 2007·Current Opinion in Obstetrics & Gynecology
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Annual Review of Medicine
David E Cummings, M W Schwartz
Annual Review of Psychology
S C WoodsR J Seeley
Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease
John R Speakman
© 2022 Meta ULC. All rights reserved