Is bisphenol A exposure associated with the development of glucose intolerance and increased insulin resistance in Thais?

Nutrition and Health
La-Or ChailurkitBoonsong Ongphiphadhanakul

Abstract

Bisphenol A (BPA), the monomeric component of polycarbonate plastics, reportedly possesses endocrine-disrupting effects. Exposure to low levels of BPA during more vulnerable periods leads to abnormalities related to sexual development in experimental animals. Moreover, recently a few epidemiological studies in Caucasians have demonstrated the association of BPA exposure with type 2 diabetes. Therefore, in the present study we examined the association of BPA exposure and abnormal glucose tolerance in Thais. This is a cross-sectional study of 240 participants aged at least 50 years, randomly selected by computer-generated random numbers within each glucose tolerance status from an oral glucose tolerance study of 661 participants. There were 80 participants in each group of type 2 diabetes, impaired glucose tolerance (IGT) and normal glucose tolerance (NGT). Serum BPA was measured by competitive ELISA. The detection rate of BPA was significantly higher in participants with IGT compared to those with NGT ( p < 0.05), while no difference was found between participants with type 2 diabetes and NGT. When participants with type 2 diabetes were stratified into those with fasting plasma glucose (FPG) under the diabetic threshold (<126 mg...Continue Reading

References

Apr 3, 1998·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·N E SkakkebaekJ Müller
Feb 17, 2000·Journal of Chromatography. B, Biomedical Sciences and Applications·J SajikiJ Yonekubo
Jan 7, 2004·British Journal of Pharmacology·Kenichi SakuraiChisato Mori
Apr 7, 2005·Environmental Health Perspectives·Antonia M CalafatLarry L Needham
Jan 6, 2006·Environmental Health Perspectives·Paloma Alonso-MagdalenaAngel Nadal
Jun 20, 2006·Molecular and Cellular Endocrinology·Maricel V MaffiniAna M Soto
Jul 25, 2006·Toxicology·Jeong-Hun KangYoshiki Katayama
Apr 24, 2007·Environmental Health Perspectives·Perinaaz R WadiaAna M Soto
Nov 1, 2007·International Journal of Andrology·A B RoperoA Nadal
May 1, 2008·PloS One·Paloma Alonso-MagdalenaAngel Nadal
Sep 19, 2008·JAMA : the Journal of the American Medical Association·Iain A LangDavid Melzer
May 22, 2010·Environmental Health Perspectives·Paloma Alonso-MagdalenaAngel Nadal
Oct 1, 2011·The Journal of Clinical Endocrinology and Metabolism·Anoop Shankar, Srinivas Teppala
Nov 18, 2011·The Journal of Clinical Endocrinology and Metabolism·Tiange WangGuang Ning
Jan 10, 2012·Molecular and Cellular Endocrinology·Paloma Alonso-MagdalenaÁngel Nadal
Apr 25, 2012·International Journal of Clinical Oncology·Bo DuanJie Luo
Aug 21, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Justin TeeguardenDaniel R Doerge
Sep 24, 2013·Journal of Toxicology and Environmental Health. Part a·Candace RobledoJean R Goodman
Apr 30, 2015·Journal of Diabetes Research·Suwannee ChanprasertyothinBoonsong Ongphiphadhanakul
May 15, 2015·The Journal of Endocrinology·Min Kyong MoonKyong Soo Park
Nov 3, 2015·The Journal of Clinical Endocrinology and Metabolism·Yufang BiGuang Ning
Jan 29, 2016·Reviews in Endocrine & Metabolic Disorders·Nicolas Chevalier, Patrick Fénichel

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Citations

Jan 21, 2021·International Journal of Environmental Research and Public Health·Francesca FarrugiaNikolai Paul Pace
Mar 23, 2020·Environmental Toxicology and Pharmacology·Muhammad Sajid Hamid AkashKanwal Rehman

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