Is breast-conserving therapy adequate in BRCA 1/2 mutation carriers? The radiation oncologist's point of view

The British Journal of Radiology
Alexis VallardCyrus Chargari

Abstract

Breast conserving therapy (BCT) is currently a recognized alternative to mastectomy for early BC patients. However, the therapeutic index of BCT was considered controversial for decades in BRCA1/2 mutation carriers. The aim of the present review was to investigate the outcome of mutation carriers undergoing BCT regarding local and distant endpoints. A short review was performed from the point of view of the radiation oncologist. Only retrospective data were available regarding local outcome assessment. They generated conflicting results. In studies with limited follow-up, BCT did not increase the risk of local recurrence in BRCA1/2 mutation carriers versus non-carriers. Conversely, some studies with longer follow-up supported that local relapse was increased in mutation carriers. Yet, according to some publications, their long-term risk of ipsilateral recurrence post-BCT was not different from general population cohorts. Besides, overall and metastasis-free survivals were the same after BCT regardless of the BRCA1/2 mutation status. Similar survival rates were also reported when BCT and mastectomy were compared in mutation carriers. Regarding acute or late toxicity, normal rates were reported in BRCA mutation carriers after bre...Continue Reading

References

Oct 7, 1994·Science·P A FutrealY Miki
Jul 31, 1998·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·D K GaffneyL A Cannon-Albright
Nov 5, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·L C VerhoogJ G Klijn
Dec 22, 1999·Journal of the National Cancer Institute·M RobsonK Offit
Oct 3, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·L J PierceB L Weber
Nov 10, 2000·International Journal of Radiation Oncology, Biology, Physics·T LeongM McKay
Feb 8, 2002·Cell·Ashok R Venkitaraman
May 4, 2002·Lancet·Bruce G HafftyMayra Alvarez-Franco
Apr 28, 2004·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C SeynaeveC T M Brekelmans
Dec 3, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C T M BrekelmansJ G M Klijn
Apr 26, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lori J PierceBarbara L Weber
Dec 6, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Susan ShanleyRosalind Eeles
Dec 7, 2006·Journal of the National Cancer Institute·Kenneth Offit
Feb 20, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C T M BrekelmansJ G M Klijn
Apr 10, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sining Chen, Giovanni Parmigiani
Feb 1, 2008·International Journal of Radiation Oncology, Biology, Physics·Bas KreikeMarc J van de Vijver
Mar 25, 2009·American Journal of Clinical Oncology·Alain FourquetUNKNOWN Institut Curie Breast Ovary Cancer Risk Study Group
Aug 4, 2009·Annals of Surgical Oncology·Carlos A Garcia-EtienneBernardo Bonanni
Jan 12, 2011·Breast Cancer Research and Treatment·Kelly MetcalfeSteven A Narod
Aug 21, 2013·International Journal of Radiation Biology·Hyojung ParkJeong Eon Lee
Feb 26, 2014·Breast Cancer Research and Treatment·Antonis ValachisPehr Lind
Sep 5, 2014·Breast Cancer Research and Treatment·Martin P NilssonNiklas Loman
Apr 3, 2015·Cold Spring Harbor Perspectives in Biology·Rohit PrakashMaria Jasin

❮ Previous
Next ❯

Citations

Apr 30, 2020·Journal of Surgical Oncology·Mary K LaddUNKNOWN other members of the Surgery After Genetic Evaluation Study Group
Aug 31, 2020·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Reiko Yoshida
Jul 29, 2019·Breast Cancer Research and Treatment·R M TrimboliF Sardanelli
Oct 28, 2019·Annals of Laboratory Medicine·Anbok LeeTae Hyun Kim
Feb 27, 2021·Deutsches Ärzteblatt International·Ulrike HoellerTheodor Hans Eich
May 25, 2021·Deutsches Ärzteblatt International·Ulrike HoellerHans Theodor Eich
May 21, 2021·Breast Cancer : Targets and Therapy·Grazia LazzariGiovanni Silvano

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Cancer: BRCA1 & BRCA2

Mutations involving BRCA1, found on chromosome 17, and BRCA2, found on chromosome 13, increase the risk for specific cancers, such as breast cancer. Discover the last research on breast cancer BRCA1 and BRCA2 here.