Is calcium the second messenger of 1-methyladenine in meiosis reinitiation of starfish oocytes?

Experimental Cell Research
A Picard, M Dorée

Abstract

Microinjection of EGTA into prophase-blocked oocytes does not inhibit hormone-induced meiosis reinitiation, although it prevents oocyte activation by fertilization, by ionophore A23187, or by subsequent microinjection of otherwise efficient Ca2+ buffers. In contrast microinjection of Ca2+ buffers inhibits 1-methyladenine-induced meiosis reinitiation. Oocytes can be released from Ca2+ inhibition by raising hormone concentration or by the subsequent transfer of cytoplasm taken from maturing oocytes. Ca2+-microinjected oocytes remain inhibited up to 1 h after microinjection, although free Ca2+ concentration comes back to its resting value less than 30 sec after microinjection. Cyanide, which decreases ATP content and depresses Ca2+-pumping activity, reversibly inhibits 1-methyladenine-induced meiosis reinitiation. These results do not support the hypothesis that Ca2+ is the second messenger of the hormone in meiosis reinitiation of starfish oocytes, although they support the view that elimination of Ca2+ from some component of the oocyte cortex (perhaps the plasma membrane) might be a compulsory event for transduction of the hormonal message.

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Citations

Aug 1, 1990·Developmental Biology·K ChibaL A Jaffe
Nov 1, 1984·The Journal of Cell Biology·A Eisen, G T Reynolds
Mar 26, 1998·Biochemical and Biophysical Research Communications·L Santella
Nov 14, 1998·Biochemical and Biophysical Research Communications·L SantellaK Kyozuka
May 1, 1983·Experimental Cell Research·A Picard, M Dorée
Feb 24, 2007·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Hiroaki TosujiKeiichiro Kyozuka

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