Is cannabidiol a drug acting on unconventional targets to control drug-resistant epilepsy?

Epilepsia Open
Luisa RochaAlberto Lazarowski

Abstract

Cannabis has been considered as a therapeutic strategy to control intractable epilepsy. Several cannabis components, especially cannabidiol (CBD), induce antiseizure effects. However, additional information is necessary to identify the types of epilepsies that can be controlled by these components and the mechanisms involved in these effects. This review presents a summary of the discussion carried out during the 2nd Latin American Workshop on Neurobiology of Epilepsy entitled "Cannabinoid and epilepsy: myths and realities." This event was carried out during the 10th Latin American Epilepsy Congress in San José de Costa Rica (September 28, 2018). The review focuses to discuss the use of CBD as a new therapeutic strategy to control drug-resistant epilepsy. It also indicates the necessity to consider the evaluation of unconventional targets such as P-glycoprotein, to explain the effects of CBD in drug-resistant epilepsy.

References

Mar 1, 1975·European Journal of Pharmacology·M Ten HamP Lomax
Mar 1, 1990·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·D J Harvey, R Mechoulam
Aug 1, 1973·Experimental Neurology·M E CorcoranJ A Wada
Oct 23, 1973·Psychopharmacologia·I G Karniol, E A Carlini
Mar 16, 1973·Psychopharmacologia·W O BogganD X Freedman
Sep 24, 1982·European Journal of Pharmacology·P ConsroeR Mechoulam
Apr 1, 1982·Pharmacology, Biochemistry, and Behavior·B K ColasantiC R Craig
Aug 1, 1981·Journal of Clinical Pharmacology·E A Carlini, J M Cunha
Mar 6, 2003·CNS Drugs·J Ludovic Croxford
Mar 31, 2004·Cellular and Molecular Neurobiology·Alberto LazarowskiElena Girardi
Apr 23, 2005·Stroke; a Journal of Cerebral Circulation·Kenichi MishimaMichihiro Fujiwara
Nov 1, 2005·Neurochemical Research·Ethan B RussoKeith K Parker
Jan 28, 2006·The Journal of Pharmacology and Experimental Therapeutics·Hao-Jie ZhuC Lindsay Devane
Feb 21, 2006·Naunyn-Schmiedeberg's Archives of Pharmacology·Markus KathmannEberhard Schlicker
Feb 13, 2007·Clinical Biochemistry·Jeffrey LópezJosé Y Bauzá
Mar 8, 2008·Epilepsia·Annamaria VezzaniEleonora Aronica
Mar 4, 2008·Molecular Pharmacology·Robert W RobeySusan E Bates
Sep 19, 2008·Expert Opinion on Drug Metabolism & Toxicology·Derek J Roberts, Kerry B Goralski
Apr 3, 2009·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Anna MazurJeffery H Moran
Dec 3, 2009·Expert Review of Neurotherapeutics·Tiziana GranataDamir Janigro
Dec 8, 2010·Nature Reviews. Neurology·Annamaria VezzaniTallie Z Baram
May 3, 2011·Biological & Pharmaceutical Bulletin·Lucia Renee RuhaakLars Bohlin
Nov 8, 2011·Epilepsy & Behavior : E&B·Mehdi Ghasemi, Steven C Schachter
Apr 24, 2012·Seizure : the Journal of the British Epilepsy Association·Nicholas A JonesClaire M Williams

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Citations

Oct 1, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Fotini GeorgiouChrystalla Matsentidou
Apr 8, 2020·Frontiers in Behavioral Neuroscience·Jerónimo AuzmendiAlberto Lazarowski
Dec 17, 2020·Journal of Alzheimer's Disease : JAD·Amalia MerelliJerónimo Auzmendi

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