Is Cannabidiol a Promising Substance for New Drug Development? A Review of its Potential Therapeutic Applications

Critical Reviews in Eukaryotic Gene Expression
Nida NoreenMuhammad Irfan Anwar

Abstract

The pharmacological importance of cannabidiol (CBD) has been in study for several years. CBD is the major nonpsychoactive constituent of plant Cannabis sativa and its administration is associated with reduced side effects. Currently, CBD is undergoing a lot of research which suggests that it has no addictive effects, good safety profile and has exhibited powerful therapeutic potential in several vital areas. It has wide spectrum of action because it acts through endocannabinoid receptors; CB1 and CB2 and it also acts on other receptors, such as GPR18, GPR55, GPR 119, 5HT1A, and TRPV2. This indicates its therapeutic value for numerous medical conditions because of its neuroprotective and immunomodulatory properties. Potential therapeutic applications of CBD include, analgesic, anti-inflammatory, anxiolytic, anti-arthritic, anti-depressant, anti-Alzheimer disease, anti-ischemic, neuroprotective, and anti-fibrotic. More promising areas appear to include diabetes and cancer where CBD exhibits lesser side effects and more therapeutic benefits as compared to recent available medical therapies. Hence, CBD is a promising substance for the development of new drug. However further research and clinical studies are required to explore its...Continue Reading

Citations

Feb 23, 2019·Critical Reviews in Toxicology·Andrea G BarthwellKenneth Egli
Dec 6, 2019·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·DanDan WeiXuHong Lin
Sep 15, 2020·Cannabis and Cannabinoid Research·Madison WrightBruna Brands
Mar 19, 2019·Current Opinion in Neurology·Cristina TassorelliStephen D Silberstein
Jan 6, 2021·AAPS PharmSciTech·Eleftherios G AndriotisDimitrios G Fatouros
Jul 9, 2021·Phytotherapy Research : PTR·Pradeep KumarAwdhesh Kumar Mishra
Sep 10, 2019·Chemico-biological Interactions·Maria Rosa Trentin ZorzenonCecília Edna Mareze-Costa

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