Is Cd11c and Fmc7 Negativity in Chronic Lymphocytic Leukemia Poor Prognostic?

Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion
Aysun Şentürk Yikilmazİmdat Dilek

Abstract

Chronic lymphocytic leukemia (CLL) is a common hematological malignancy. This study is aimed to investigate the prognostic effect of clinic, laboratory and flow cytometric analysis in CLL patients. Newly diagnosed 55 CLL cases were divided into two groups, as stable disease (Group 1) and progressive disease (Group 2). Group 1 included those who did not require any treatment since diagnosis and those who did not progress after receiving the first step anti CLL treatment. Group 2 included the patients who received ≥ 2 steps treatment. The relation between the two groups was analyzed statistically in terms of clinical, laboratory and flow cytometric findings. Twenty patients (36.3%) required treatment at the time of diagnosis, four patients (3.8%) received first-line treatment during follow-up and 31 (56.3%) patients were followed without any treatment. Thirteen patients required second step treatment after a median of 26.3 months. The risk of progression was found to be increased 5-fold (p = 0.015) in the CD38 positive patient group, 4.2-fold (p = 0.0147) in the FMC7 negative patient group and 2.8-fold in the CD11c negative patient group. FMC 7 negativity decreased total survival 5.9-fold (p = 0.051). Unlike similar publications,...Continue Reading

References

Aug 16, 2002·British Journal of Haematology·Tryfonia Mainou-FowlerGeoffrey P Summerfield
Sep 19, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Avadhut D JoshiShantaram S Joshi
May 2, 2008·Blood Reviews·Carol Moreno, Emili Montserrat
Sep 1, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·B EichhorstUNKNOWN ESMO Guidelines Committee
Oct 16, 2015·Nature·Dan A LandauCatherine J Wu
Dec 1, 2015·Cancer Control : Journal of the Moffitt Cancer Center·Lodovico Balducci, Dawn Dolan
Dec 1, 2015·Cancer Control : Journal of the Moffitt Cancer Center·Javier Pinilla-Ibarz, Josephine Emole
Jun 13, 2017·International Journal of Laboratory Hematology·E G UmitA M Demir
Nov 11, 2017·Blood Reviews·Alain MinaMohamed A Kharfan-Dabaja

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